The current study examined contiguous cycles of jaw movement in order to determine if select suprasegmental manipulations operate globally across the entire utterance, while phonetic changes are more locally administered. Specifically, articulatory kinematics were examined to determine if intra- and inter-articulatory spatial and temporal organization across manipulations of speaking rate was maintained for both jaw cycles while differing between the two cycles for phonetic changes (i.e., in coda composition) specific to the second jaw cycle. Five normal speakers repeated the syllables /paep/, /paeps/, and /paepst/, embedded in the carrier phrase, "Now say again," using slow, normal, and fast speaking rates. Measures were made of the magnitude of jaw opening peak velocity and time to peak velocity, as well as of coarticulatory overlap and interarticulator timing, for the first jaw cycle (jaw lowering for /eI/ in "say" to the first /p/) and the second jaw cycle (jaw lowering for /ae/ to the second /p/). The current data indicate that, for intra-articulatory kinematics, the manipulation of phonetic context resulted in localized adjustments, whereas the manipulation of speaking rate was applied globally across the utterance. Conversely, for inter-articulatory kinematics, the upper lip-jaw synergy was reconfigured across the utterance for manipulations of speaking rate, whereas this synergy was maintained for localized manipulations in phonetic context. Results are discussed with respect to motor strategies being flexibly implemented as a result of contextual variation and speech rate.
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http://dx.doi.org/10.1044/1092-4388(2002/053) | DOI Listing |
J Assist Reprod Genet
January 2025
Brussels IVF, Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium.
Purpose: This survey aimed to assess the public's knowledge and opinions on oocyte donation (OD) among a large, unselected cohort of young Belgian women, and to explore aspects that could be enhanced to promote future OD programs.
Methods: We conducted a quantitative, epidemiological, cross-sectional web-based survey from February 2023 to April 2023. A private questionnaire was distributed to young women (21-30 years) living in Belgium via a digital link.
Nat Commun
January 2025
Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
We conducted a phase I trial to determine the optimal dose of triplet therapy with the tyrosine kinase inhibitor sitravatinib plus nivolumab plus ipilimumab in 22 previously untreated patients with advanced clear cell renal cell carcinoma. The primary endpoint was safety. Secondary endpoints were objective response rate (ORR), disease control rate (DCR), duration of response (DOR), progression-free survival (PFS), overall survival (OS), 1-year survival probability, and sitravatinib pharmacokinetics.
View Article and Find Full Text PDFClin Linguist Phon
January 2025
Département de Logopédie, RUCHE, Université de Liège, Liège, Belgique.
Speech sound disorders (SSD) are associated with difficulties in communication, social participation, literacy, and learning. An early identification process is therefore necessary. Our study was aimed at determining the utility and accuracy of parent's and teacher's concerns in screening for SSD.
View Article and Find Full Text PDFBMC Med Educ
January 2025
Center for Health Literacy, Careum Foundation, Zurich, 8032, Switzerland.
Background: Health professionals play a key role in promoting health literacy, as they continue to be one of the main points of contact and most trusted source of information for healthcare users on questions and concerns regarding health and disease. To adequately support individuals in dealing with health information and services and to strengthen health literacy, health professionals need a corresponding set of knowledge, skills, and attitudes, hence they need a wide range of health literacy competencies. Despite their crucial role in guiding and supporting patients and their relatives in terms of health-related information and services, in-depth studies on health literacy competencies of health professionals are still scarce.
View Article and Find Full Text PDFLung
January 2025
National Reference Center for Rare Pulmonary Diseases, Louis Pradel Hospital, Hospices Civils de Lyon, Claude Bernard University Lyon 1, UMR 754, ERN-LUNG, Lyon, France.
Purpose: In the INBUILD trial in patients with progressive pulmonary fibrosis (PPF), nintedanib slowed the decline in forced vital capacity (FVC) versus placebo, with a safety profile characterised mainly by gastrointestinal events. INBUILD-ON, the open-label extension of INBUILD, assessed the safety of nintedanib during longer-term treatment. Data on FVC were collected.
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