AI Article Synopsis
- Calycosin was isolated from the root of Astragalus membranaceus using high-speed counter-current chromatography.
- The purification involved a two-step process with a specific solvent combination of n-hexane, chloroform, methanol, and water.
- From an initial 200 mg of crude extract, 14.8 mg of calycosin was successfully obtained with over 99% purity, confirmed through HPLC and various spectroscopy techniques.
Article Abstract
Calycosin was purified from an ethyl acetate extract of the root of Astragalus membranaceus Bge. var. mongholicus (Bge.) Hsiao by high-speed counter-current chromatography. The separation was performed in two steps with a two-phase solvent system composed of n-hexane-chloroform-methanol-water (1:3:3:2, v/v). From 200 mg of the crude extract, 14.8 mg of calycosin was obtained at over 99% purity as determined by HPLC analysis, and its chemical structure was confirmed by MS, 1H and 13C nuclear magnetic resonance.
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| http://dx.doi.org/10.1016/s0021-9673(02)00535-6 | DOI Listing |
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