Studies were undertaken to evaluate lead-induced environmental pollution in the urban and rural areas of Mongolia. There was a correlation between blood lead levels in children and the lead pollution of air, soil, snow cover, which is well known to affect children's morbidity.
Download full-text PDF |
Source |
---|
Neuroscience
January 2025
Department of Radiation Biology and Toxicology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India. Electronic address:
Lead (Pb) is an environmental toxin ubiquitously present in the human environment due to anthropogenic activities and industrialization. Lead can enter the human body through various sources and pathways, such as inhalation, ingestion and dermal contact, leading to detrimental health effects. The majority of lead that enters the body is removed by urine or feces; however, under chronic exposure conditions, lead is not efficient, as lead is absorbed and transferred to numerous organs, such as the brain, liver, kidney, muscles, and heart, and it is ultimately stored in mineralizing tissues such as bones and teeth.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; MOE Key Laboratory of Environment Correlative Dietology, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:
This study investigated the protective effects and Pb-excretion mechanisms of yeast glucans (YG) with varying oxidation degrees in Pb-exposed mice. Results demonstrated that all three glucans effectively reduced blood lead levels, alleviated inflammation, and mitigated liver damage in Pb-exposed mice, with highly oxidized yeast glucan (OYG2) exhibiting the greatest efficacy. Furthermore, the glucans attenuated Pb-induced oxidative stress and pathological changes in the kidney by elevating glutathione and superoxide dismutase levels, thereby restoring renal excretory function (blood urea nitrogen and creatinine).
View Article and Find Full Text PDFEcotoxicol Environ Saf
December 2024
Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, China; Department of Toxicology, School of Public Health, Southern Medical University, Guangzhou 510515, China; School of Public Health, Sun Yat-sen University, Guangzhou 510080, China; School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China. Electronic address:
Lead (Pb) exposure is widely acknowledged as a risk factor for cardiovascular diseases. Previous studies have established neutrophil involvement in Pb-induced cardiovascular injuries; however, the underlying mechanisms remain unclear. To address this knowledge gap, the binding targets of Pb in neutrophils and their roles in regulating neutrophil extracellular trap (NET) formation were investigated.
View Article and Find Full Text PDFEcotoxicol Environ Saf
December 2024
Department of Theriogenology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.
Food Chem Toxicol
December 2024
Department of Environmental Health, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, 1838 Guangzhou Road North, Guangzhou, 510515, PR China. Electronic address:
Lead is a ubiquitous environmental chemical with various toxic damage to human body. This investigation aimed to explore the intervention effect of human umbilical cord mesenchymal stem cells derived exosomes (HUC-MSC-exo) on the neurotoxicity of lead and the relevant mechanism. Differential gradient ultracentrifugation was adopted to isolate HUC-MSC-exo.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!