The fluidisation and dispersion properties of various agarose-based expanded bed matrices--small high density stainless steel cored prototypes and standard commercial types--were studied in 1-cm diameter expanded bed contactors in which fluid entering the column base is locally stirred. In all cases, fluidisation behaviour was poorly predicted from the Richardson-Zaki correlation, with experimentally determined values of the expansion index being considerably higher than the theoretical values. The resons for these discrepancies are discussed in detail and the validity of applying this widely used correlation for characterisation of expanded bed systems is questioned. Residence time distribution studies using acetone tracers, demonstrated that in comparison to existing commercial supports, the small pellicular prototype materials generally possessed far superior hydrodynamic properties, which augurs well for their future employment in expanded bed chromatographic separations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0021-9673(02)00590-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Decellularized Liver Matrices for Expanding the Donor Pool-An Evaluation of Existing Protocols and Future Trends.
Biomolecules
January 2025
Department of General, Transplant, and Liver Surgery, Medical University of Warsaw, 02-091 Warsaw, Poland.
Liver transplantation is the only curative option for end-stage liver disease and is necessary for an increasing number of patients with advanced primary or secondary liver cancer. Many patient groups can benefit from this treatment, however the shortage of liver grafts remains an unsolved problem. Liver bioengineering offers a promising method for expanding the donor pool through the production of acellular scaffolds that can be seeded with recipient cells.
View Article and Find Full Text PDFAnalysis of geological characteristics and potential factors of formation damage in coalbed methane reservoir in Northern Qinshui basin.
Sci Rep
January 2025
School of petroleum engineering, Yangtze University, Wuhan, 430100, China.
Given the suboptimal physical properties and distinctive geological conditions of deep coalbed methane reservoirs, any reservoir damage that occurs becomes irreversible. Consequently, the protection of these deep coalbed methane reservoirs is of paramount importance. This study employs experimental techniques such as scanning electron microscopy, X-ray diffraction, and micro-CT imaging to conduct a comprehensive analysis of the pore structure, mineral composition, fluid characteristics, and wettability of coal seams 3# and 15# in the northern Qinshui Basin of China.
View Article and Find Full Text PDFPreventable hospitalizations through ED: does the number of hospital beds matter under the global budget in a single-payer system in Taiwan?
Front Public Health
January 2025
Division of Medical Statistics and Bioinformatics, Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City, Taiwan.
Background: Taiwan implemented global hospital budgeting with a floating-point value, which created a prisoner's dilemma. As a result, hospitals increased service volume, which caused the floating-point value to drop to less than one New Taiwan Dollar (NTD). The recent increase in the number of hospital beds and the call to enhance the floating-point value to one NTD raise concerns about the potential for increased financial burden without adding value to patient care if hospitals expand their bed capacity for volume-based competition.
View Article and Find Full Text PDFQuantifying crystallinity of amlodipine maleate in amorphous solid dispersions produced by fluidized bed granulation using PAT tools.
Eur J Pharm Sci
January 2025
Faculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, Slovenia; KRKA, d. d., 8501 Novo Mesto, Slovenia. Electronic address:
One of the main concerns with formulations containing amorphous solid dispersions (ASDs) is their physical stability. Stability can be compromised if a formulation contains any residual crystallinity of an active pharmaceutical ingredient (API) that could act as seeds for further crystallisation. This study presents four methods for crystalline amlodipine maleate quantification in ASD, which were developed using one Raman and three NIR process analysers.
View Article and Find Full Text PDFFactors associated with malaria in pregnancy among women attending ANC clinics in selected districts of the Ashanti Region, Ghana.
Malar J
January 2025
Family and Community Health, Fred N. Binka School of Public Health, University of Health and Allied Sciences, Hohoe, Ghana.
Background: Malaria is a disease deeply rooted in poverty. Malaria in pregnant women leads to severe complications, including low birth weight and neonatal mortality, which can adversely affect both mother and child. This study aimed to identify the factors associated with malaria in pregnancy among women attending antenatal care (ANC) clinics in three districts of the Ashanti Region, Ghana.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!