Numerous psychotropic drugs exist as a mixture of 2 mirror-image stereoisomers of each other, each called an enantiomer and the mixture called a racemate. Often the drug can be improved when only 1 of the enantiomers is administered.
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A mirror-image experiment: Sorting carbon nanotubes by L-DNA.
PNAS Nexus
January 2025
Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003, USA.
DNA has found increasing applications in molecular engineering, yet its chiral property has rarely been utilized. Here, we report a mirror-image experiment using naturally occurring D-DNA and its enantiomer L-DNA to sort a chiral mixture of single-wall carbon nanotubes (SWCNTs). We find that parity conservation leads to a robust experimental outcome: changing DNA chirality results in handedness inversion of the purified nanotube.
View Article and Find Full Text PDFHippocampal Functional Radiomic Features for Identification of the Cognitively Impaired Patients from Low-Back-Related Pain: A Prospective Machine Learning Study.
J Pain Res
January 2025
Jiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Radiology, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People's Republic of China.
Purpose: To investigate whether functional radiomic features in bilateral hippocampi can identify the cognitively impaired patients from low-back-related leg pain (LBLP).
Patients And Methods: For this retrospective study, a total of 95 clinically definite LBLP patients (40 cognitively impaired patients and 45 cognitively preserved patients) were included, and all patients underwent functional MRI and clinical assessments. After calculating the amplitude of low-frequency fluctuations (ALFF), regional homogeneity (ReHo), voxel-mirrored homotopic connectivity (VMHC) and degree centrality (DC) imaging, the radiomic features (n = 819) of bilateral hippocampi were extracted from these images, respectively.
Computational Study Protocol: Leveraging Synthetic Data to Validate a Benchmark Study for Differential Abundance Tests for 16S Microbiome Sequencing Data.
F1000Res
January 2025
Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Baden-Württemberg, Germany.
Background: Synthetic data's utility in benchmark studies depends on its ability to closely mimic real-world conditions and reproduce results obtained from experimental data. Building on Nearing et al.'s study (1), who assessed 14 differential abundance tests using 38 experimental 16S rRNA datasets in a case-control design, we are generating synthetic datasets that mimic the experimental data to verify their findings.
View Article and Find Full Text PDFNeuroenhancement by repetitive transcranial magnetic stimulation (rTMS) on DLPFC in healthy adults.
Cogn Neurodyn
December 2025
CIPCE, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, North Kargar Ave., Tehran, Iran.
The term "neuroenhancement" describes the enhancement of cognitive function associated with deficiencies resulting from a specific condition. Nevertheless, there is currently no agreed-upon definition for the term "neuroenhancement", and its meaning can change based on the specific research being discussed. As humans, our continual pursuit of expanding our capabilities, encompassing both cognitive and motor skills, has led us to explore various tools.
View Article and Find Full Text PDFThree-dimensional analysis of facial morphology in nine-year-old children with different unilateral orofacial clefts compared to normative data.
PeerJ
January 2025
Section of Orthodontics and Craniofacial Biology, Department of Dentistry, Radboud University Medical Center, Nijmegen, Netherlands.
Aim: To compare three-dimensional (3D) facial morphology of various unilateral cleft subphenotypes at 9-years of age to normative data using a general face template and automatic landmarking. The secondary objective is to compare facial morphology of 9-year-old children with unilateral fusion to differentiation defects.
Methods: 3D facial stereophotogrammetric images of 9-year-old unilateral cleft patients were imported into 3DMedX® for processing.
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