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Severe Acute Liver Injury After Hepatotoxic Medication Initiation in Real-World Data.
JAMA Intern Med
August 2024
Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Importance: Current approaches to classify the hepatotoxic potential of medications are based on cumulative case reports of acute liver injury (ALI), which do not consider the size of the exposed population. There is little evidence from real-world data (data relating to patient health status and/or the delivery of health care routinely collected from sources outside of a research setting) on incidence rates of severe ALI after initiation of medications, accounting for duration of exposure.
Objective: To identify the most potentially hepatotoxic medications based on real-world incidence rates of severe ALI and to examine how these rates compare with categorization based on case reports.
Application of immune checkpoint inhibitors and microsatellite instability in gastric cancer.
World J Gastroenterol
June 2024
Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.
Article Synopsis
- The editorial discusses the increasing role of immune checkpoint inhibitors (ICIs) and microsatellite instability (MSI) in the treatment of gastric cancer (GC), highlighting immunotherapy as a new "fifth pillar" alongside traditional treatments like surgery and chemotherapy.
- ICIs, particularly targeting the PD-1/PD-L1 pathway with drugs like nivolumab and pembrolizumab, show promise in treating advanced GC, but may cause serious immune-related adverse events that require careful monitoring.
- Detecting MSI-high or mismatch-repair-deficient tumors is crucial before administering ICIs, as these tumors respond well to immunotherapy, improving treatment outcomes.
Comments on "Clinically relevant therapeutic approaches against acetaminophen (APAP) hepatotoxicity and acute liver failure".
Biochem Pharmacol
July 2024
Department of Radiology, Innlandet Trust Hospital, Gjøvik Hospital, 2819 Gjøvik, Norway.
Placing a Report of Bicalutamide-Induced Hepatotoxicity in the Context of Current Standards of Care for Transgender Adolescents.
J Adolesc Health
January 2024
Division of Endocrinology, Boston Children's Hospital/Harvard Medical School, Boston, Massachusetts.
AASLD practice guidance on drug, herbal, and dietary supplement-induced liver injury: also useful for hepatobiliary surgeons.
Hepatobiliary Surg Nutr
October 2023
Service of Gastroenterology and Hepatology, University Hospital Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma Bionand, Universidad de Málaga, Málaga, Spain.
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