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The Transcription Factor StuA Regulates Oxidative Stress-Responsive Genes in .
Int J Mol Sci
December 2024
Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil.
Fungi can remarkably sense and adapt to various extracellular stimuli and stress conditions. Oxidative stress, which results from an imbalance between reactive oxygen species production and antioxidant defenses, leads to cellular damage and death. In , oxidative stress is managed by a complex antioxidant system, including thioredoxins, glutathione, catalases, peroxidases, and superoxide dismutase, with glutathione playing a crucial role.
View Article and Find Full Text PDFClassical swine fever: Unveiling the complexity through a multifaceted approach.
Open Vet J
October 2024
School of Agriculture and Food Sustainability, The University of Queensland, Gatton QLD, Queensland.
Classical swine fever (CSF), sometimes referred to as hog cholera, is a highly contagious, virally based, systemic illness that affects both domestic and wild pigs. The virus known as classical swine fever virus (CSFV) is a member of the Flaviviridae family, specifically the genus Pestivirus. This disease is thought to be endemic in many Asian countries that produce pork as well as in several countries in Central and South America, the Caribbean, and elsewhere.
View Article and Find Full Text PDFEstablishment and characterization of an immortalized red river hog blood-derived macrophage cell line.
Front Immunol
September 2024
Division of Transboundary Animal Disease Research, National Institute of Animal Health, National Agriculture and Food Research Organization, Kodaira, Japan.
Red river hogs (RRHs) (), a wild species of living in Africa with a major distribution in the Guinean and Congolian forests, are natural reservoirs of African swine fever virus (ASFV) and typically are asymptomatic. Since blood and tissue macrophages of suid animals are target cell lineages of ASFV, RRH-derived macrophages are expected to play an important role in suppressing disease development in infected individuals. In the present study, we successfully isolated RRH-derived blood macrophages using co-culture techniques of RRH blood cells with porcine kidney-derived feeder cells and immortalized them by transferring SV40 large T antigen and porcine telomerase reverse transcriptase genes.
View Article and Find Full Text PDFparticipates in the regulation of spore production, stress response, and pigments synthesis in .
PeerJ
September 2024
Guizhou Key Laboratory of Agricultural Biotechnology, Guiyang, Guizhou, China.
Article Synopsis
- A filamentous fungus was studied because it makes different types of spores based on stress levels, which could help us understand how these fungi reproduce.
- A specific gene, SI65_02513, was found to be important in the fungus's ability to deal with stress and help produce spores, but more research is needed.
- Experiments showed that when this gene was removed, the fungus produced much fewer spores and struggled to grow under stress compared to normal fungi, indicating it plays a key role in their survival.
Rapid Differential Detection of Wild-Type Classical Swine Fever Virus and Hog Cholera Lapinized Virus Vaccines by TaqMan MGB-Based Dual One-Step Real-Time RT-PCR.
Vet Sci
June 2024
College of Biological and Pharmaceutical Engineering, Jilin Agricultural Science and Technology University, Jilin 132101, China.
To establish a rapid real-time RT-PCR method for differentiating wild-type classical swine fever virus (CSFV) strains from vaccine strains (HCLV), we designed a universal primer targeting the gene to detect wild-type CSFV strains and vaccine strains simultaneously, and two TaqMan-MGB probes were designed to differentiate between wild-type and vaccine strains. After optimizing the RT-qPCR conditions, a rapid dual TaqMan-MGB RT-qPCR method for the detection and identification of CSFV and HCLV was developed. The results showed that method could specifically detect CSFV and HCLV with no cross-reactivity with other swine pathogens.
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