Study Design: Acute progression of spondylolysis to spondylolisthesis in an adult without degenerative disc disease at the slip level is reported.
Objective: To document a case of adult-onset progression of isthmic spondylolisthesis, in which the disc space height at the slip level was normal. There were no known risk factors for progression, and the olisthesis occurred acutely after minimal trauma.
Summary Of Background Data: Adult progression of spondylolysis to spondylolisthesis is reported infrequently because the highest risk for slip progression is before skeletal maturity. Previous reports documenting progressive slips in adults have uniformly related the olisthesis to progressive disc collapse and subluxation below the pars defect.
Methods: A 39-year-old woman was evaluated for a primary complaint of back and bilateral leg pain. Standing radiographs of her lumbar spine showed an L4-L5 and L5-S1 spondylolysis without spondylolisthesis. She had severe degenerative disc changes at L5-S1. The disc space height was normal at L4-L5. Two years later she was essentially immobilized by back pain after minimal trauma. Standing radiographs demonstrated a new Grade 2 L4-L5 isthmic spondylolisthesis. As demonstrated by magnetic resonance imaging, spontaneous reduction of the olisthesis has occurred with normal disc space height maintained.
Results: An L4-S1 anterior lumbar interbody fusion and posterior decompression and spinal fusion with instrumentation were performed without complication. At this writing, the patient has returned to work and is doing well 1 year after surgery.
Conclusions: This case is important because it illustrates the potential for acute progression of spondylolisthesis with minimal trauma. A patient with known spondylolysis who sustains acute severe exacerbation of his or her back pain should have repeat standing radiographs.
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Sci Adv
January 2025
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
The cytokine interleukin-10 (IL-10) limits the immune response and promotes resolution of acute inflammation. Because of its immunosuppressive effects, IL-10 up-regulation is a common feature of tumor progression and metastasis. Recently, IL-10 regulation has been shown to depend on mitochondria and redox-sensitive signals.
View Article and Find Full Text PDFShock
February 2025
Department of Respiratory and Critical Care Medicine, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.
Background: Ubiquitination and deubiquitination are involved in the progression of human diseases, including acute pneumonia. In this study, we aimed to explore the functions of ubiquitin-specific peptidase 9X-linked (USP9X) in lipopolysaccharide (LPS)-treated WI-38 cells. Methods: WI-38 cells were treated with LPS to induce the cellular damage and inflammation.
View Article and Find Full Text PDFSchizophr Bull
January 2025
Department of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, China.
Background And Hypothesis: Identifying biomarkers at onset and specifying the progression over the early course of schizophrenia is critical for better understanding of illness pathophysiology and providing novel information relevant to illness prognosis and treatment selection. Studies of antipsychotic-naïve first-episode schizophrenia in China are making contributions to this goal.
Study Design: A review was conducted for how antipsychotic-naïve first-episode patients were identified and studied, the investigated biological measures, with a focus on neuroimaging, and how they extend the understanding of schizophrenia regarding the illness-related brain abnormality, treatment effect characterization and outcome prediction, and subtype discovery and patient stratification, in comparison to findings from western populations.
Lung
January 2025
Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Background: Guidelines specify steroids as therapy for acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, the duration of survival benefit associated with steroids and the optimal dosage of nebulized budesonide (NB) during hospitalization remain unclear.
Methods: We conducted a retrospective study of hospitalized AECOPD patients.
Cureus
December 2024
Internal Medicine, Griffin Hospital, Derby, USA.
Ethylene glycol (C₂H₆O₂), a toxic alcohol commonly found in automotive antifreeze, de-icing solutions, and industrial coolants, can cause severe toxicity when ingested. Due to its sweet taste, it is often consumed accidentally or intentionally, leading to life-threatening consequences such as metabolic acidosis, acute kidney injury (AKI), and mortality. Prompt diagnosis and early treatment with antidotes such as fomepizole or ethanol, combined with hemodialysis, are essential in preventing severe outcomes.
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