A patient with multiple odontogenic fibroma-like tumors in the mandible and enamel dysplasia is presented, bringing the total number of cases reported in the literature to 3. In addition to these manifestations, this case had hypodontia. The absence of associated teeth, the size of the lesions, the lingual expansion, and the green-yellow polarization of collagen with Picrosirius stains supported the neoplastic nature of the central odontogenic fibroma-like tumors in the case presented. Laminated psammomatous deposits distinguished the tumors from the World Health Organization-type central odontogenic fibroma.
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http://dx.doi.org/10.1067/moe.2002.124862 | DOI Listing |
Hua Xi Kou Qiang Yi Xue Za Zhi
February 2025
Dept. of Oral and Maxillofacial Surgery, Zibo Central Hospital, Zibo 255036, China.
Pathological fractures after jaw cyst surgery are rare clinically but are a serious complication. Once a pathological fracture occurs, treatment time and economic costs increase, and doctors face difficulty in handling it. This article reports a case of a patient with mandibular pathological fractures after multiple odontogenic keratocyst surgery of the jaw.
View Article and Find Full Text PDFInt Arch Otorhinolaryngol
January 2025
Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.
There are no clear guidelines for deciding between endoscopic sinus surgery and tooth extraction for the treatment of odontogenic sinusitis. Furthermore, tooth extraction does not necessarily improve sinusitis and eventually results in additional endoscopic sinus surgery. The present study aimed to retrospectively investigate negative predictive factors of tooth extraction for odontogenic sinusitis.
View Article and Find Full Text PDFHGG Adv
January 2025
Department of Surgery, Division of Orthopaedics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. Electronic address:
SOX9 encodes an SRY-related transcription factor critical for chondrogenesis and sex determination among other processes. Loss-of-function variants cause campomelic dysplasia and Pierre Robin Sequence, while both gain- and loss-of-function variants cause disorders of sex development. SOX9 has also been linked to scoliosis and cancers, but variants are undetermined.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Department of Pharmacy, "G. d'Annunzio" University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
Dental inflammatory diseases remain a challenging clinical issue, whose causes and development are still not fully understood. During dental caries, bacteria penetrate the tooth pulp, causing pulpitis. To prevent pulp necrosis, it is crucial to promote tissue repair by recruiting immune cells, such as macrophages, able to secrete signal molecules for the pulp microenvironment and thus to recruit dental pulp stem cells (DPSCs) in the damaged site.
View Article and Find Full Text PDFJ Adv Res
January 2025
Center of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China; School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China; Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430022, People's Republic of China. Electronic address:
Introduction: Establishing an optimized regenerative microenvironment for pulp-dentin complex engineering has become increasingly critical. Recently, exosomes have emerged as favorable biomimetic nanotherapeutic tools to simulate the developmental microenvironment and facilitate tissue regeneration.
Objectives: This study aimed to elucidate the multifaceted roles of exosomes from human dental pulp stem cells (DPSCs) that initiated odontogenic differentiation while sustaining mesenchymal stem cell (MSC) characteristics in odontogenesis, angiogenesis, and neurogenesis during pulp-dentin complex regeneration.
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