A case of hyponatraemia occurring in a 69-year-old diabetic woman taking chlorpropamide is reported. Increasing the dose of chlorpropamide aggravated the hyponatraemia, and the condition corrected itself when the chlorpropamide was withdrawn. It is believed, therefore, that, in the absence of any other cause for the hyponatraemia, chlorpropamide was the cause.
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http://dx.doi.org/10.5694/j.1326-5377.1975.tb106395.x | DOI Listing |
Front Physiol
December 2021
Institute of Biomedical Science, Hanyang University College of Medicine, Seoul, South Korea.
Hyponatremia is frequently encountered in clinical practice and usually induced by renal water retention. Many medications are considered to be among the various causes of hyponatremia, because they either stimulate the release of arginine vasopressin (AVP) or potentiate its action in the kidney. Antidepressants, anticonvulsants, antipsychotics, diuretics, and cytotoxic agents are the major causes of drug-induced hyponatremia.
View Article and Find Full Text PDFTohoku J Exp Med
December 1995
Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai.
Chlorpropamide (CPM) has been reported to produce impaired water excretion due to the enhancement of renal vasopressin (ADH) action and/or due to centrally enhanced ADH release, but it is still unknown whether CPM gives rise to ADH release with a subsequent hyponatremia in diabetes mellitus (DM), which, in turn, causes an impairment of the central nervous system. In 3 patients with DM, who developed hyponatremia during the treatment with CPM, an acute water load (WL) was carried out in the presence and absence of the drug, and plasma ADH was determined with plasma and urine osmolalities. Moreover, in 2 cases, MRI scans of the brain were taken.
View Article and Find Full Text PDFAnn Pharmacother
October 1992
Department of Veterans Affairs Medical Center, Long Beach, CA.
Objective: To determine the incidence and possible risk factors associated with chlorpropamide (CPA)-induced hyponatremia in the veteran population.
Design: Retrospective cohort study.
Setting: Federal tertiary care medical center.
J Assoc Physicians India
August 1991
PD Hinduja National Hospital & Research Centre, Mahim, Bombay.
This is a report of a patient who developed symptomatic hyponatraemia during chlorpropamide therapy for diabetes mellitus. The patient's clinical and biochemical abnormalities were corrected by withdrawal of chlorpropamide. This represents a drug induced, reversible form of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH).
View Article and Find Full Text PDFDiabetes Care
March 1989
Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan.
The incidence and risk factors of chlorpropamide-induced hyponatremia were assessed in diabetic outpatients. In 176 chlorpropamide-treated patients, 11 (6.3%) exhibited hyponatremia (serum sodium less than or equal to 129 meq/L) during the mean follow-up period of 7.
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