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Inhibitory and Curative Effects and Mode of Action of Hydroxychloroquine on of Tomato.
Phytopathology
January 2025
Guizhou University, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Huaxi District, Guiyang, Guizhou Province of China, Guiyang, China, 550025;
Gray mold is an important disease of crops and is widespread, harmful, difficult to control, and prone to developing fungicide resistance. Screening new fungicides is an important step in controlling this disease. Hydroxychloroquine is an anti-inflammatory and anti-malarial agent, which has shown marked inhibitory activity against many fungi in medicine.
View Article and Find Full Text PDFEnvironmental impact of disposable face masks: degradation, wear, and cement mortar incorporation.
Environ Sci Pollut Res Int
January 2025
CERENA - Civil Engineering Research and Innovation for Sustainability, IST-ID, Av. António José de Almeida 12, 1049-001, Lisbon, Portugal.
Polypropylene (PP) disposable face masks (DFMs) are essential for limiting airborne infectious diseases. This study examines the behavior of DFMs under three scenarios: (i) exposure to the natural environment, (ii) simulated high-energy aquatic environments through an abrasion test, and (iii) incorporation into cement-based mortars. In the natural weathering experiment, after 117 days, the DFMs exhibited photodegradation, resulting in chemical alterations in carbonyl and hydroxyl groups.
View Article and Find Full Text PDFThe association between immunoinflammatory biomarkers NLR, PLR, LMR and nonalcoholic fatty liver disease: a systematic review and meta-analysis.
Clin Exp Med
January 2025
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, No. 110 Ganhe Road, Shanghai, 200437, China.
Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disorder closely linked to metabolic syndrome. Identifying novel, easily measurable biomarkers could significantly enhance the diagnosis and management of NAFLD in clinical settings. Recent studies suggest that immunoinflammatory biomarkers-specifically, the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR)-may offer diagnostic value for NAFLD.
View Article and Find Full Text PDFPatient perceptions of osteoporosis management: a qualitative pilot study by a patient advisory group.
Arch Osteoporos
January 2025
Department of Rheumatology and ULR 4490 (MabLab), University-Hospital of Lille, Lille, France.
Unlabelled: The management of osteoporosis even after a fracture is declining. Our pilot study in patients with osteoporosis confirms a large ignorance of the disease and major fears and uncertainties about the treatments. Complete and sustained medical information seems essential to counteract the contradictory information, which are exclusively negative.
View Article and Find Full Text PDFPharmacodynamic characterization and evaluation of oxidative stress effects of digitoxigenin derivatives on HeLa cells.
J Membr Biol
January 2025
Laboratório de Bioquímica Celular, Universidade Federal de São João del-Rei (UFSJ), Divinópolis, Brazil.
Cancer is a leading cause of death worldwide and its treatment is hampered by the lack of specificity and side effects of current drugs. Cardiotonic steroids (CTS) interact with Na/K-ATPase (NKA) and induce antineoplastic effects, but their narrow therapeutic window is key limiting factor. The synthesis of digitoxigenin derivatives with glycosidic unit modifications is a promising approach to develop more selective and effective antitumor agents.
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