This brief review encapsulates a nearly 50-year career in biomedical research, primarily studying human leukemias and lymphomas, but also involving normal lymphocytes. Early observations included the feasibility of bone marrow transplantation (and related problems with graft-vs.-host reactions); the mitogenic effect of phytohemagglutinin (and resultant human lymphocyte culture techniques); and early cytogenetic findings in human leukemias, both lymphocytic and myeloid (including the Philadelphia chromosome). Subsequent studies of normal human lymphocytes have contributed to our enormously expanding knowledge of their basic biology, especially regulatory pathways, both extracellular and intracellular. Further work with human lymphoid neoplasms has helped extend the early chromosomal findings to the specific genes involved, including several regulating apoptosis; and also contributed to the concept of clonal evolution as a basic underlying mechanism of tumorigenesis in general. This career has covered a period of remarkable growth of knowledge concerning both normal and neoplastic lymphocytes, with potential for many important future clinical applications; it has been a privilege to participate.
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http://dx.doi.org/10.1034/j.1600-065x.2002.18518.x | DOI Listing |
J Pediatr Endocrinol Metab
January 2025
Department of Pediatric Endocrinology, Kocaeli City Hospital, Kocaeli, Türkiye.
Objectives: This study aimed to identify clinical features of girls referred to a pediatric endocrinology clinic for suspected precocious puberty, differentiate true precocious puberty from other variants, evaluate treatment status, and identify distinguishing factors between patient groups.
Methods: We retrospectively evaluated the records of 275 consecutive girls aged 0-10 years referred for suspected precocious puberty.
Results: Among the patients, 30 (10.
Res Pract Thromb Haemost
January 2025
Department of Emergency and Critical Care Medicine, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Background: Acute aortic dissection is a life-threatening cardiovascular emergency with high mortality rates. Disseminated intravascular coagulation (DIC) is a critical complication in patients with acute aortic dissection; however, its incidence and impact on outcomes remain inconclusive.
Objectives: This study aimed to evaluate DIC prevalence and prognosis in patients with aortic dissection.
Int J Dev Disabil
May 2023
Department of Special Education, Faculty of Education, East China Normal University, Shanghai, China.
This study investigates Chinese general education teachers' perceptions of teaching assistants' (TAs) support for students with intellectual and developmental disabilities (IDD). We administered open-ended questionnaires to 358 participating teachers and interviewed eight participants. The results showed that teachers perceived behavioural and emotional adjustment among students with IDD as a significant benefit of TA support.
View Article and Find Full Text PDFInt J Dev Disabil
May 2023
Department of Special Education, San Francisco State University, San Francisco, CA, USA.
This study evaluated the psychometric properties of the Chinese translation of the Self-Determination Inventory: Parent/Teacher Report (Chinese SDI: PTR). The Chinese SDI: PTR was used in an online survey of parents of students with intellectual disabilities ( = 340) and parents of students without disabilities ( = 354) to explore their perspectives on their children's self-determination. Factor structure, measurement invariance, and latent differences across the Chinese SDI: PTR groups were examined.
View Article and Find Full Text PDFInt J Dev Disabil
June 2023
School of Education Science, Xinjiang Normal University, Urumqi, China.
Executive dysfunction has been widely reported in children with autism spectrum disorder (ASD). Although studies have demonstrated the intervention effect of sports game and pretend play on children's executive function, few studies have examined the effect of Comprehensive games, and similar studies in children with ASD are scarce. In order to investigate the effect of different games on the executive functions of preschool children with ASD, 24 preschool children with ASD were selected in this study.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!