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Probing the effect of a 3'-S-phosphorothiolate link on the conformation of a DNA:RNA hybrid; implications for antisense drug design. | LitMetric
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Probing the effect of a 3'-S-phosphorothiolate link on the conformation of a DNA:RNA hybrid; implications for antisense drug design.

Andrew P G Beevers Kevin J Fettes Ian A O'Neil Stanley M Roberts John R P Arnold Richard Cosstick Julie Fisher

Chem Commun (Camb)

Department of Chemistry, University of Leeds, Leeds, UK LS2 9JT.

Published: July 2002

The effects of a single 3'-S-phosphorothiolate link in the DNA strand of a DNA:RNA dodecamer duplex is described; the sulfur induces a conformational shift in the (attached) sugar pucker, as shown by 1H NMR studies, and increases the thermal stability of the duplex compared to the non-modified system.

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 Source
http://dx.doi.org/10.1039/b203582kDOI Listing

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