AI Article Synopsis
- The explosion of information from human genome sequencing has created a need for cost-effective and flexible options in fields like genomics, proteomics, and drug discovery.
- Many companies are exploring the development of large chemical libraries on colloidal support beads, which allow for a vast range of compounds to be accessed in a single experiment.
- This article discusses innovative methods for using optical barcoding to organize and identify these colloidal compounds, particularly focusing on the challenge of labeling very large libraries to improve research in various scientific domains.
Article Abstract
The enormous amount of information generated through sequencing of the human genome has increased demands for more economical and flexible alternatives in genomics, proteomics and drug discovery. Many companies and institutions have recognised the potential of increasing the size and complexity of chemical libraries by producing large chemical libraries on colloidal support beads. Since colloid-based compounds in a suspension are randomly located, an encoding system such as optical barcoding is required to permit rapid elucidation of the compound structures. We describe in this article innovative methods for optical barcoding of colloids for use as support beads in both combinatorial and non-combinatorial libraries. We focus in particular on the difficult problem of barcoding extremely large libraries, which if solved, will transform the manner in which genomics, proteomics and drug discovery research is currently performed.
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| http://dx.doi.org/10.1039/b200038p | DOI Listing |
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