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Developing the biomarker panels and drugs by proteomic analysis for autoimmune uveitis and posterior scleritis.
iScience
December 2024
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Autoimmune uveitis and posterior scleritis are ocular diseases caused by immune dysregulation. Their pathogenesis remains elusive, and delayed diagnosis can exacerbate vision loss. Our study analyzed proteomic profiles of 190 patients with Behcet's disease uveitis, posterior scleritis, and Vogt-Koyanagi-Harada syndrome.
View Article and Find Full Text PDFPattern of Uveitis in Northern Vietnam.
Ocul Immunol Inflamm
December 2024
Department of Ophthalmology, Hanoi Medical University, Hanoi, Vietnam.
Purpose: To characterize the spectrum of uveitis in patients visiting three tertiary hospitals in Hanoi, Vietnam.
Methods: This study collected prospective and multicenter data from patients diagnosed with uveitis at three tertiary hospitals in Hanoi City, Vietnam, between January 2022 and January 2024. Data on age, sex, clinical and laboratory findings, and etiology were collected.
Advances in the Study of the Pathogenesis of Vogt-Koyanagi-Harada Syndrome.
Curr Mol Med
October 2024
Department of Ophthalmology, China-Japan Union Hospital, Jilin University, Changchun, Jilin 130033, P.R. China.
Article Synopsis
- Vogt-Koyanagi-Harada syndrome (VKHS) is a prevalent uveitis that targets melanocyte-rich tissues, with increasing incidence and unclear pathogenesis.
- The condition typically affects the posterior segment of the eye, causing serious issues like retinal detachment and chorioretinitis, potentially leading to vision loss if not treated promptly.
- This study aims to explore the underlying mechanisms of VKHS and summarizes current research to enhance understanding and guide future studies in the field.
Association between axial length and uveitis.
Graefes Arch Clin Exp Ophthalmol
October 2024
Department of Ophthalmology, Tokyo Medical University, Tokyo, 160-0023, Japan.
Article Synopsis
- The study investigates the link between myopia (nearsightedness) and uveitis by comparing the axial lengths (AL) of eyes affected by uveitis to those of healthy controls.
- A total of 1052 eyes from uveitis patients and 738 control eyes were analyzed, revealing that the median AL in uveitis patients was significantly shorter than in controls, indicating a potential relationship.
- Specifically, the research found that shorter AL correlates with a higher risk of developing uveitis, with each millimeter decrease in AL increasing risk by 1.266 times.
Irisin Alleviates Autoimmune Uveitis Through Promoting Retinal Microglial M1 to M2 Phenotypic Polarization Mediated by HIF-1α Pathway.
Inflammation
September 2024
Department of Ophthalmology, Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, The First Affiliated Hospital of Zhengzhou University, Henan International, Henan Province Eye Hospital, Zhengzhou, P.R. China.
Article Synopsis
- Irisin is a special hormone made when we exercise, and scientists studied its levels in the eyes of people with certain eye diseases called uveitis.
- They found that people with these diseases had lower levels of irisin, and more irisin seemed to help reduce the inflammation and bad effects of the disease in experiments with mice.
- The research also showed that irisin help balance some immune cells in the body and can affect a pathway in the retina that makes the inflammation worse.
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