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Stabilized porous liposomes with encapsulated Gd-labeled dextran as a highly efficient MRI contrast agent.
Chem Commun (Camb)
March 2014
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
A highly efficient contrast agent for magnetic resonance imaging was developed by encapsulating gadolinium within a stabilized porous liposome. The highly porous membrane leads to a high relaxivity of the encapsulated Gd. The stability of the liposome was improved by forming a polymer network within the bilayer membrane.
View Article and Find Full Text PDFIn vivo quantitative assessment of cell viability of gadolinium or iron-labeled cells using MRI and bioluminescence imaging.
Contrast Media Mol Imaging
July 2013
Department of Radiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
In cell therapy, noninvasive monitoring of in vivo cell fate is challenging. In this study we investigated possible differences in R₁, R₂ or R₂* relaxation rate as a measure of overall cell viability for mesenchymal stem cells labeled with Gd-liposomes (Gd-MSCs) or iron oxide nanoparticles (SPIO-MSCs). Cells were also transduced with a luciferase vector, facilitating a correlation between MRI findings and cell viability using bioluminescence imaging (BLI).
View Article and Find Full Text PDFCationic Gd-DTPA liposomes for highly efficient labeling of mesenchymal stem cells and cell tracking with MRI.
Cell Transplant
August 2012
Department of Radiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
In the current study cell labeling was performed with water-soluble gadolinium (Gd)-DTPA containing liposomes, to allow for cell tracking by MRI. Liposomes were used to assure a highly concentrated intracellular build up of Gd, aiming to overcome the relatively low MRI sensitivity of Gd (compared to T2 contrast agents). Liposomes were positively charged (cationic) to facilitate uptake by binding to anionic charges in the cell membrane of bone marrow-derived mesenchymal stem cells (MSCs).
View Article and Find Full Text PDFCombined delivery and magnetic resonance imaging of neural cell adhesion molecule-targeted doxorubicin-containing liposomes in experimentally induced Kaposi's sarcoma.
Cancer Res
March 2010
Department of Internal Medicine and Center for Molecular Imaging, University of Turin, Turin, Italy.
Specific targeting of tumors by combined delivery of drugs and of imaging agents represents an attractive strategy for treatment of cancer. The aim of the present study was to investigate whether neural cell adhesion molecule (NCAM)-targeted liposomes may enhance drug delivery and allow magnetic resonance imaging (MRI) in a severe combined immunodeficient mouse model of NCAM-positive Kaposi's sarcoma. NCAM-binding peptide-coated liposomes loaded with both doxorubicin and a lipophilic gadolinium (Gd) derivative were generated.
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