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Hydrological classification of mine pit lakes using modelling experiments.
J Environ Manage
November 2024
Centre for Water in the Minerals Industry, Sustainable Minerals Institute, The University of Queensland, Brisbane, Australia.
With the growing global prevalence of open-pit mining activities, there is an increasing necessity for sustainable mine life cycle plans with an early outlook towards mine closure. A major consideration in mine closure planning is the potential formation of lakes in the mine void and how these "pit lakes" can be managed to minimise risks and, if possible, create benefits. Understanding the long-term interactions between pit lakes, groundwater, and surface water systems is essential for that purpose.
View Article and Find Full Text PDFTherapeutic potentials and targeting strategies of quercetin on cancer cells: Challenges and future prospects.
Phytomedicine
October 2024
Department of Chemistry, School of Advanced Science, Vellore Institute of Technology, Vellore, 632014 Tamil Nadu, India. Electronic address:
Article Synopsis
- Quercetin, a flavonoid found in plants, has been studied for its potential anti-cancer properties and targets various cancer cell signaling pathways, leading to cell death (apoptosis).* -
- The research highlights the pros and cons of using quercetin in cancer treatment, noting its effectiveness as well as issues like hydrophobicity and gastrointestinal instability that hinder its pharmaceutical use.* -
- Future advancements may involve utilizing bio-nanomaterials to improve the delivery and efficacy of quercetin in targeting cancer cells effectively.*
Equilibrium phase contrast-enhanced magnetic resonance angiography of the thoracic aorta and heart using balanced T1 relaxation-enhanced steady-state.
J Cardiovasc Magn Reson
December 2024
Department of Radiology, Northshore University HealthSystem, Evanston, Illinois, USA; Department of Radiology, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA.
Background: Three-dimensional (3D) contrast-enhanced magnetic resonance angiography (CEMRA) is routinely used for vascular evaluation. With existing techniques for CEMRA, diagnostic image quality is only obtained during the first pass of the contrast agent or shortly thereafter, whereas angiographic quality tends to be poor when imaging is delayed to the equilibrium phase. We hypothesized that prolonged blood pool contrast enhancement could be obtained by imaging with a balanced T1 relaxation-enhanced steady-state (bT1RESS) pulse sequence, which combines 3D balanced steady-state free precession (bSSFP) with a saturation recovery magnetization preparation to impart T1 weighting and suppress background tissues.
View Article and Find Full Text PDFIncreased In Vivo Exposure of N-(4-Hydroxyphenyl) Retinamide (4-HPR) to Achieve Plasma Concentrations Effective against Dengue Virus.
Pharmaceutics
July 2023
Nuclear Signalling Laboratory, Department Biochem. & Mol. Biol., Biomedicine Discovery Institute, Monash University, Clayton 3800, Victoria, Australia.
N-(4-hydroxyphenyl) retinamide (4-HPR, or fenretinide) has promising in vitro and in vivo antiviral activity against a range of flaviviruses and an established safety record, but there are challenges to its clinical use. This study evaluated the in vivo exposure profile of a 4-HPR dosage regime previously shown to be effective in a mouse model of severe dengue virus (DENV) infection, comparing it to an existing formulation for human clinical use for other indications and developed/characterised self-emulsifying lipid-based formulations of 4-HPR to enhance 4-HPR in vivo exposure. Pharmacokinetic (PK) analysis comprising single-dose oral and IV plasma concentration-time profiles was performed in mice; equilibrium solubility testing of 4-HPR in a range of lipids, surfactants and cosolvents was used to inform formulation approaches, with lead formulation candidates digested in vitro to analyse solubilisation/precipitation prior to in vivo testing.
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