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Association of Sleep Spindle Rate With Memory Consolidation in Children With Rolandic Epilepsy.
Neurology
January 2025
Department of Neurology, Massachusetts General Hospital, Boston.
Background And Objectives: Rolandic epilepsy (RE), the most common childhood focal epilepsy syndrome, is characterized by a transient period of sleep-activated epileptiform activity in the centrotemporal regions and variable cognitive deficits. Sleep spindles are prominent thalamocortical brain oscillations during sleep that have been mechanistically linked to sleep-dependent memory consolidation in animal models and healthy controls. Sleep spindles are decreased in RE and related sleep-activated epileptic encephalopathies.
View Article and Find Full Text PDFUltimate water capillary evaporation in bamboo-inspired evaporator.
Mater Horiz
January 2025
Natural Sciences and Science Education, National Institute of Education, Nanyang Technological University, Singapore 637616, Singapore.
Bionic evaporators inspired by natural plants like bamboo and mushrooms have emerged as efficient generators through water capillary evaporation. However, primitive natural evaporators cannot currently meet growing demand, and their performance limitations remain largely unexplored, presenting a substantial challenge. Through extensive experimentation and detailed simulation analysis, this study presents a precisely engineered H-type bamboo steam generator.
View Article and Find Full Text PDFIntestinal interstitial fluid isolation provides novel insight into the human host-microbiome interface.
Cardiovasc Res
January 2025
Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Aims: The gastrointestinal (GI) tract is composed of distinct sub-regions, which exhibit segment-specific differences in microbial colonization and (patho)physiological characteristics. Gut microbes can be collectively considered as an active endocrine organ. Microbes produce metabolites, which can be taken up by the host and can actively communicate with the immune cells in the gut lamina propria with consequences for cardiovascular health.
View Article and Find Full Text PDFIntracellular Retention of Estradiol is Mediated by GRAM Domain-Containing Protein ASTER-B in Breast Cancer Cells.
Mol Cancer Res
January 2025
The University of Texas Southwestern Medical Center, Dallas, TX, United States.
Elevated blood levels of estrogens are associated with poor prognosis in estrogen receptor-positive (ER+) breast cancers, but the relationship between circulating blood hormone levels and intracellular hormone concentrations are not well characterized. We observed that MCF-7 cells treated acutely with 17β-estradiol (E2) retain a substantial amount of the hormone even upon removal of the hormone from the culture medium. Moreover, global patterns of E2-dependent gene expression are sustained for hours after acute E2 treatment and hormone removal.
View Article and Find Full Text PDFTextbook Neoadjuvant Experience: Defining a Novel Composite Outcomes Measure for Patients with Pancreatic Cancer Undergoing Neoadjuvant Therapy.
J Am Coll Surg
January 2025
Division of Surgical Oncology, Department of Surgery, The Ohio State University, Columbus, OH.
Background: Neoadjuvant therapy (NT) is increasingly utilized for patients with pancreatic ductal adenocarcinoma (PDAC). Disease progression, toxicity, and failure to undergo surgical resection are common during NT, yet little research has focused on efforts to optimize care delivery. We sought to define and validate a novel composite outcomes metric that characterizes the successful delivery of NT.
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