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J Ethnopharmacol
March 2025
Jiangsu Key Laboratory of Children's Health and Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China; Medical Metabolomics Center, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:
Ethnopharmacological Relevance: Platycodon grandiflorus root, is a widely used herb in East Asia for treating respiratory diseases, but research on its oral safety is limited.
Aim Of The Study: This study examines the potential adverse gastrointestinal reactions resulting from excessive consumption of Platycodon grandiflorus root (PR) and its effects on gut microbiota and host co-metabolism.
Materials And Methods: This study evaluated the effects of different doses (1.
Annu Int Conf IEEE Eng Med Biol Soc
July 2024
Chronic Intestinal Pseudo-Obstruction in children (CIPO) comprises a group of ultra-rare and debilitating diseases characterized by severe motility defects affecting the entire digestive tract. With limited effective therapies, particularly for myopathic CIPO, we aim at characterizing the behavior of an intestinal smooth muscle cell line undergoing a set of chemical and physical stimulations, to assess their effect. To this end, we adopted healthy Human Intestinal Smooth Muscle Cells, plated on standard coverslips and, for the first time, Micro Electrode Arrays (MEAs).
View Article and Find Full Text PDFCureus
January 2025
Internal Medicine, JCHO Sakuragaoka Hospital, Shizuoka, JPN.
Intestinal pseudo-obstruction caused by aerophagia is predominantly observed in children with developmental delays, and adult cases are rare. Cases are typically managed symptomatically because there are no known effective treatments. We report here a successful response to intestinal pseudo-obstruction in an adult patient presenting with chronic abdominal distention.
View Article and Find Full Text PDFJ Trauma Acute Care Surg
March 2025
From Emergency and Trauma Surgery Unit, Department of General Surgery (F.M.B., G.M., D.D.), IRCCS Humanitas Research Hospital; Department of Biomedical Sciences (F.M.B., G.W.L.P., G.M.), Humanitas University; Department of General Surgery (D.Z., G.W.L.P.), IRCCS Humanitas Research Hospital, Milan; Hepatobiliary Surgery Unit (S.F.), Fondazione Policlinico Universitario A. Gemelli, IRCCS, Catholic University of the Sacred Heart, Rome, Italy; and IRCAD (S.F.), Research Institute Against Cancer of the Digestive System, Strasbourg, France, Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico, Milan, Italy (F.M.B).
Introduction: The open abdomen (OA) technique is nowadays a worldwide strategy both for trauma and emergency general surgery. Despite the attempt at conducting prospective studies, a high level of evidence is far from established. The aim of this study was to investigate if we overused this strategy and if it improved the postoperative course of our patients.
View Article and Find Full Text PDFBMJ Case Rep
February 2025
Medical Gastroenterology, Dr DY Patil Medical College, Hospital & Research Center, Dr. DY Patil Vidyapeeth (Deemed to be University), Pimpri, Pune, Maharashtra, India.
Systemic lupus erythematosus (SLE) is an autoimmune inflammatory condition with a varied clinical presentation. It can involve multiple organ systems and has the potential to impact any part of the gastrointestinal tract. Intestinal pseudo-obstruction (IPO) is a rare yet severe gastrointestinal manifestation of SLE.
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