Of the two components of the word genome, 'ome' is the more interesting.
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| http://dx.doi.org/10.1186/gb-2002-3-7-comment1010 | DOI Listing |
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Nonheme Mononuclear and Dinuclear Iron(II) and Iron(III) Fluoride Complexes and Their Fluorine Radical Transfer Reactivity.
Inorg Chem
January 2025
Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, United States.
The nonheme iron(II) complexes containing a fluoride anion, Fe(BNPAO)(F) () and [Fe(BNPAOH)(F)(THF)](BF) (), were synthesized and structurally characterized. Addition of dioxygen to either or led to the formation of a fluoride-bridged, dinuclear iron(III) complex [Fe(BNPAO)(F)(μ-F)] (), which was characterized by single-crystal X-ray diffraction, H NMR, and elemental analysis. An iron(II)(iodide) complex, Fe(BNPAO)(I) (), was prepared and reacted with O to give the mononuclear complex -Fe(BNPAO)(OH)(I) ().
View Article and Find Full Text PDFThe long-term efficacy and safety of balloon dilation eustachian tuboplasty combined with tympanostomy tube insertion for patients with otitis media with effusion: study protocol for a prospective randomized controlled trial.
Trials
August 2024
Department of Otorhinolaryngology, Eye and ENT Hospital of Fudan University, Shanghai, China.
Article Synopsis
- Otitis media with effusion (OME) is commonly caused by eustachian tube dysfunction and leads to problems like hearing loss; traditional treatment with tympanostomy tube insertion (TTI) alleviates symptoms but is not a definitive cure.
- The study aims to assess the effectiveness of a new procedure, balloon dilation eustachian tuboplasty (BDET), in combination with TTI in patients with OME through a randomized controlled trial involving 124 participants.
- Outcomes will be measured over two years using various assessments to evaluate eustachian tube function, middle ear function, hearing improvement, and quality of life, marking an important investigation into the long-term benefits and safety of this combined treatment.
Biosafety assessment of novel organoselenium zidovudine derivatives in the Caenorhabditis elegans model.
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Federal University of Santa Maria, Center for Natural and Exact Sciences, Department of Biochemistry and Molecular Biology, Postgraduate Program in Biological Sciences: Toxicological Biochemistry, Camobi, Zip code 97105-900 Santa Maria, RS, Brazil. Electronic address:
Antiretrovirals have improved considerably since the introduction of 3'-azido-3'-deoxythymidine (zidovudine or AZT), a molecule with also anticancer effects. Subsequently, a variety of other nucleosides have been synthesized. However, these medications are often associated with serious adverse events and the onset or exacerbation of degenerative processes, diseases, and syndromes, affecting mainly the mitochondria.
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Basic Science Department, Faculty of Physical Therapy, Benha University, Benha 13511, Egypt.
Researchers are focusing on understanding the etiology and predisposing factors of chronic nonspecific low back pain (CNSLBP), a costly prevalent and disabling disorder. Related clinical, functional, and biomechanical variables are often studied, but in isolation. We aimed to identify key factors for managing CNSLBP by examining the relationship between back disability and related clinical, functional, and biomechanical variables and developed prediction models to estimate disability using various variables.
View Article and Find Full Text PDFTuning Intramolecular Charge Transfer in Antimony(V) Porphyrin through Axial Fluorination.
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Advanced Materials Center, University of Minnesota Duluth, 1405 University Drive, Duluth, Minnesota 55812, United States.
Modulation of intramolecular charge transfer (ICT) has been tested in two antimony(V) porphyrins, SbT(DMP)P(OMe)·PF and SbT(DMP)P(OTFE)·PF, where the -positions are occupied by 3,5-dimethoxyphenyl (DMP), and the axial positions are linked with either methoxy (OMe) or trifluoroethoxy (OTFE) units, respectively. The presence of the Sb(+5) ion makes the porphyrin center electron poor. Under this situation, placing electron-rich units in the -position creates a condition for push-pull type ICT in the SbT(DMP)P(OMe)·PF.
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