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Can Bariatric Surgery Help to Prevent Autoimmunity?
Arch Med Res
July 2023
Medical Research Institute, Evangelical Mackenzie University, Curitiba, Paraná, Brazil; Department of Medicine, Mackenzie Evangelical School of Medicine Paraná, Curitiba, Paraná, Brazil.
Background: Obesity has been linked to the development and progression of autoimmune diseases.
Aim: To investigate the presence of autoantibodies in the sera of bariatric-surgery patients.
Methods: During the pre- and postoperative period, sera from 79 patients undergoing bariatric surgery were tested for the presence of antinuclear antibodies (ANA), Rheumatoid Factor (RF), IgG and IgM anticardiolipin antibodies, and anti-endomysial antibodies.
Role of age in dynamics of autoantibodies in pediatric Celiac disease.
Ital J Pediatr
March 2023
Pediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza University of Rome, Rome, Italy.
Background: Celiac disease (CD) is characterized by elevated serum titers of autoantibodies IgA anti-tissue transglutaminase 2 (TGA-IgA) and IgA anti-endomysial (EMA), with small bowel mucosa atrophy. We evaluated age differences between CD children exhibiting variable antibody titers at diagnosis.
Methods: CD children diagnosed between January 2014 and June 2019, according to 2012 ESPGHAN guidelines were studied.
Characterization of the "gut microbiota-immunity axis" and microbial lipid metabolites in atrophic and potential celiac disease.
Front Microbiol
September 2022
Department of Biomedical, Experimental and Clinical Sciences "Mario Serio" University of Florence, Tuscany Regional Referral Center for Adult Celiac Disease, Florence, Italy.
Article Synopsis
- The study investigates the differences in microbial, lipid, and immune profiles between potential celiac disease (pCD) patients and those with atrophic celiac disease (aCD).
- It analyzes samples from 17 aCD patients, 10 pCD patients, and 12 healthy controls, focusing on serum free fatty acids (FFAs) and duodenal mucosa histology.
- Findings reveal significant differences in serum FFAs between pCD and aCD patients, and a distinct immune response, with pCD demonstrating lower CD4 T lymphocyte percentages and different T cell profiles compared to aCD patients.
SERONEGATIVE CELIAC DISEASE IN BRAZILIAN PATIENTS: A SERIES OF CASES.
Arq Gastroenterol
August 2021
UUniversidade Federal do Paraná, Hospital de Clínicas, Curitiba, PR, Brasil.
Background: Celiac disease (CD) is an autoimmune disease characterized by immune reaction mostly to wheat gluten. The diagnosis is based on clinical, serological and histological findings in patients ingesting gluten. Cases that the clinical profile indicates CD and the autoantibodies are negative bring so a dilemma for the professional, as the risk of missed the diagnosis or a delay at the same.
View Article and Find Full Text PDFNon-Biopsy Serology-Based Diagnosis of Celiac Disease in Adults Is Accurate with Different Commercial Kits and Pre-Test Probabilities.
Nutrients
September 2020
Tampere Center for Child Health Research, Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland.
Non-biopsy diagnosis of celiac disease is possible in children with anti-transglutaminase 2 antibodies (TGA) > 10× the upper limit of normal (ULN) and positive anti-endomysial antibodies (EMA). Similar criteria have been suggested for adults, but evidence with different TGA assays is scarce. We compared the performance of four TGA tests in the diagnosis of celiac disease in cohorts with diverse pre-test probabilities.
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