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A functionalized microwave biosensor for rapid, reagent-free detection of E. coli in water samples.
Biosens Bioelectron
March 2025
Department of Mechanical and Mechatronics Engineering, University of Waterloo, Canada; Water Institute, University of Waterloo, Canada; Waterloo Institute for Nanotechnology, University of Waterloo, Canada. Electronic address:
Escherichia coli (E. coli) O157:H7 (O157), one of the most common Shiga toxin-producing E. coli, can contaminate water systems causing severe illnesses often accompanied with diarrhea and sometimes life threatening.
View Article and Find Full Text PDFUse of complement C5-inhibitor eculizumab in patients with infection-associated hemolytic uremic syndrome - a case-series report.
BMC Pediatr
March 2025
Institute of Pediatrics, Faculty of Medicine, University of Debrecen, Nagyerdei Krt 98, 4028, Debrecen, Hungary.
Background: Hemolytic uremic syndrome (HUS), characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury (AKI), remains a leading cause of pediatric AKI. The complement system has a crucial role in the pathogenesis of atypical hemolytic uremic syndrome (aHUS) and eculizumab (ECZ) was approved as standard of care for its treatment. The two widely characterized forms of infection-associated HUS are Shiga toxin-producing E.
View Article and Find Full Text PDFComparative genomics of clinical hybrid Escherichia coli strains in Norway.
Int J Med Microbiol
March 2025
Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway. Electronic address:
The global rise of hybrid Escherichia coli (E. coli) is a major public health concern, as enhanced virulence from multiple pathotypes complicates the traditional E. coli classification system and challenges clinical diagnostics.
View Article and Find Full Text PDFPredicting progression of STEC-HUS: Use of Shiga toxin subtype and routine laboratory screening.
J Pediatric Infect Dis Soc
March 2025
Kaiser Permanente Northern California Pediatrics, Division Infectious Diseases, San Francisco, CA.
Background: Hemolytic uremic syndrome (HUS) is life-threatening sequelae of Shiga toxin producing Escherichia coli (STEC) enteric infection. To address ambiguity in medical literature, we aimed to identify which STEC toxin profiles and clinical variables were at highest risk of HUS progression to inform evidence-based screening guidelines.
Methods: This was a 5-year retrospective study of children aged <18 years with E.
The Minimum Growth Temperatures of Shiga Toxin-Producing .
Foodborne Pathog Dis
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Department of Poultry Science, University of Georgia, Athens, Georgia, USA.
The objective of this study was to determine the minimum growth temperature of Shiga toxin-producing (STEC). Forty-eight strains of STEC, including O157:H7, O104:H4, O26, O45, O103, O111, O121, and O145, were inoculated into tryptic soy broth (TSB) at ca. 6.
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