In 85% of Ewing family tumors, the NH2 terminus of EWS is fused to the DNA-binding domain of FLI1, an ets transcription factor. The resulting chimeric protein is a strong transcriptional activator with transforming activity. We report that EWS and EWS-FLI1 interact via their common NH2 terminus with the COOH terminus of BARD1, a putative tumor suppressor, in vitro and in vivo. Because BARD1 associates via its NH2-terminal RING domain with the breast cancer susceptibility gene BRCA1 that provides a platform for interactions with proteins involved in DNA repair and checkpoint control, our results provide a link between the Ewing's sarcoma gene product and the genome surveillance complex.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Synthesis and characterisation of DOTA-kisspeptin-10 as a potential gallium-68/lutetium-177 pan-tumour radiopharmaceutical.
J Neuroendocrinol
January 2025
Centre for Neuroendocrinology, University of Pretoria, Pretoria, South Africa.
Kisspeptin (KISS1) and its cognate receptor (KISS1R) are implicated in the progression of various cancers. A gallium-68 labelled kisspeptin-10 (KP10), the minimal biologically active structure, has potential as a pan-tumour radiopharmaceutical for the detection of cancers. Furthermore, a lutetium-177 labelled KP10 could find therapeutic application in treating oncological diseases.
View Article and Find Full Text PDFSelf-assembled Arginine-Glycine-Aspartic Acid Mimic Peptide Hydrogels as Multifunctional Biomaterials for Wound Healing.
ACS Appl Mater Interfaces
December 2024
CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India.
Clinical management of nonhealing ulcers requires advanced materials that can enhance wound closure rates without relying on the release of drugs or other growth factors to obviate systemic deleterious side effects. In our previous work, we synthesized an integrin-binding cell adhesive M {Fmoc-FFβAR(K)βA-NH consisting of an RGD mimic, [R(K)], with an amide terminus}, M {Fmoc-FFβAR(K)βA-OH consisting of an RGD mimic, [R(K)], with acid terminus}, and M (Fmoc-FFβARGDβA-NH consisting of an RGD peptide, reference) with multifunctional activity. Here, we reported the synthesis, characterization, and performance of a reversed derivative, R-M (Fmoc-FFβA(K)RβA-NH consisting of an RGD mimic, [K(R)], with an amide terminus) of an antimicrobial cell adhesive peptide, M.
View Article and Find Full Text PDFConstruction of a novel heteropoly molybdophosphate/graphitized carbon nitride s-scheme heterostructure with enhanced photocatalytic HO evolution activity.
J Colloid Interface Sci
October 2023
MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China. Electronic address:
The preparation of hydrogen peroxide using a photochemical energy conversion process is a promising green pathway. Herein, a series of graphite-phase carbon nitride/Polyoxometalate (CN-HMoP) composite photocatalysts were prepared by interlayer coordination and segregation strategies. During the synthesis process, the presence of -NH or H ions at the CN terminus makes it display a positive charge, which is capable of attracting HMoP with a polyanionic structure.
View Article and Find Full Text PDFCharacterization of a methyltransferase for iterative N-methylation at the leucinostatin termini in Purpureocillium lilacinum.
Commun Biol
June 2024
State Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, 100081, Beijing, China.
N-methyltransferase (NMT)-catalyzed methylation at the termini of nonribosomal peptides (NRPs) has rarely been reported. Here, we discover a fungal NMT LcsG for the iterative terminal N-methylation of a family of NRPs, leucinostatins. Gene deletion results suggest that LcsG is essential for leucinostatins methylation.
View Article and Find Full Text PDFAmyloid engineering - how terminal capping modifies morphology and secondary structure of supramolecular peptide aggregates.
Biomater Sci
March 2024
Institute of Advanced Materials, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland.
The effects of peptide N- and C-termini on aggregation behavior have been scarcely studied. Herein, we examine (105-115) peptide fragments of transthyretin (TTR) containing various functional groups at both termini and study their impact on the morphology and the secondary structure. We synthesized TTR(105-115) peptides functionalized with α-amino (H-), -acetyl-α-amino (Ac-) or ,-dimethyl-α-amino (DiMe-) groups at the N-terminus, and with amide (-NH) or carboxyl (-OH) functions at the C-terminus.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!