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Real-time deformable structure tracking in 3D ultrasound sequences using deformable convolutional layers.
Comput Biol Med
January 2025
University of Lübeck, Ratzeburger Allee 160, Lübeck, 23562, Schleswig-Holstein, Germany. Electronic address:
Ultrasound imaging can provide 3D images of soft tissue structures in real-time without harmful radiation. Due to its high level of availability and low-cost characteristics, it is becoming more and more interesting for therapy guidance purposes like in radiotherapy. However, for usage in radiotherapy a robust and real-time image analysis method is required to be able to track the target during the treatment session.
View Article and Find Full Text PDFMesua ferrea L. extract inhibits cell invasion and tumor growth in breast cancer in vitro and in vivo.
Tissue Cell
January 2025
College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China. Electronic address:
Mesua ferrea L. was commonly used in Uyghur medicine, and the flowering buds of M. ferrea extract exhibited significant inhibitory effects on the proliferation of breast cancer cells in our preliminary research; however, the underlying active components remain to be elucidated.
View Article and Find Full Text PDFModelling host-pathogen interactions: as a platform to study response to host-imposed zinc starvation.
Microbiology (Reading)
January 2025
Department of Biology, Tor Vergata University of Rome, Rome, Italy.
Nutritional immunity, a key component of the vertebrate innate immune response, involves the modulation of zinc availability to limit the growth of pathogens. counteracts host-imposed zinc starvation through metabolic adaptations, including reprogramming of gene expression and activating efficient metal uptake systems. To unravel how zinc shortage contributes to the complexity of bacterial adaptation to the host environment, it is critical to use model systems that mimic fundamental features of -related diseases in humans.
View Article and Find Full Text PDFSingle-cell atlas reveals multi-faced responses of losartan on tubular mitochondria in diabetic kidney disease.
J Transl Med
January 2025
Department of Endocrine Medicine, Shanghai Sixth People's Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201306, Chin, China.
Background And Objective: Mitochondria are crucial to the function of renal tubular cells, and their dynamic perturbation in many aspects is an important mechanism of diabetic kidney disease (DKD). Single-nucleus RNA sequencing (snRNA-seq) technology is a high-throughput sequencing analysis technique for RNA at the level of a single cell nucleus. Here, our DKD mouse kidney single-cell RNA sequencing conveys a more comprehensive mitochondrial profile, which helps us further understand the therapeutic response of this unique organelle family to drugs.
View Article and Find Full Text PDFSynthesis and antifungal activity of aldehydes-thiourea derivatives as promising antifungal agents against postharvest gray mold disease.
Chem Biodivers
January 2025
Chuxiong Normal University, Academy of Science and Technology, Chuxiong Normal University, Chuxiong, 675000，China, No. 456 Luchengnan Road, chuxiong, Academy of Science and Technology, 651000, chuxiong, CHINA.
Gray mold disease is caused by B. cinerea, which could severely reduce the production yield and quality of tomatoes. To explore more potential fungicides with new scaffolds for controlling the gray mold disease, ten aldehydes-thiourea derivatives were designed, synthesized and assayed for inhibitory activity against three plant pathogenic fungi.
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