AI Article Synopsis
- A study was conducted on Sprague-Dawley rats to investigate telomerase activity (TA) and telomerase reverse transcriptase (rTERT) following a 90% pancreatectomy over various time points (6 h to 14 days post-surgery).
- Telomerase activity increased significantly at 2 days post-surgery, peaking at 3 days, which correlated with the highest proliferation of small ductules in the pancreas.
- After reaching its peak, telomerase activity declined back to baseline levels as the ductules began to differentiate into new endocrine and exocrine pancreatic tissues, indicating active regulation during the regeneration process.
Article Abstract
Telomerase activity (TA) and telomerase reverse transcriptase (rTERT) were investigated in Sprague-Dawley rats, killed at 6 and 12 h, and 1, 2, 3, 7, and 14 days after 90% pancreatectomy (px), by TRAPeze enzyme-linked immunosorbent assay telomerase detection and reverse transcriptase-polymerase chain reaction. TA increased at 2 days and reached a maximum at 3 days after px, when the small ductules showed the highest proliferation activity. After 3 days, TA decreased to basal levels as the ductules differentiated into new endocrine and exocrine pancreas. The expression of rTERT showed a correlation with TA. These results suggest telomerase is actively regulated during pancreatic regeneration.
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| http://dx.doi.org/10.1016/s0304-3835(02)00320-8 | DOI Listing |
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