AI Article Synopsis
- A new group of spiroketal compounds that block NK(1) receptors is introduced.
- The study analyzes how changes to the spiroether ring and aromatic groups affect the compounds' effectiveness.
- As a result, several compounds were found to have strong binding capabilities and impressive ability to cross into the central nervous system.
Article Abstract
A series of novel spiroketal-based NK(1) antagonists is described. The effect of modifications to the spiroether ring and aromatic substituents are discussed, leading to the identification of compounds with high affinity and excellent CNS penetration.
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| http://dx.doi.org/10.1016/s0960-894x(02)00506-1 | DOI Listing |
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