Objective: The postangioplasty evaluation of a stenotic vessel is often conducted by studying serial angiograms to determine the anatomic reduction in stenosis. In flow-limiting stenosis, the hemodynamic change that accompanies these anatomic changes is of great importance in evaluating the success of the angioplasty. The purpose of this article is to demonstrate the usefulness of phase contrast magnetic resonance angiography (PCMRA) in evaluating the hemodynamic changes that occur after angioplasty of the basilar and vertebral arteries.
Methods: Between January 1998 and February 2000, PCMRA was performed for the hemodynamic evaluation of 130 patients who presented at our institution. Twenty-six patients were evaluated for vertebrobasilar insufficiency, and flow rates of their vertebral and basilar arteries were determined. In five patients, angioplasty was done on the basilar or vertebral arteries, and PCMRA was performed to determine flow rates before and after the procedure.
Results: Of the five patients undergoing angioplasty, the average percentage of stenosis was 81%. The average increase in basilar artery flow rate was 46 ml/min (P < 0.05) after angioplasty. Two of these patients are described. One patient demonstrated the comparison of flow rates in the vertebral and basilar arteries after angioplasty. The second patient showed follow-up flow rates measured after angioplasty and up to 4 months later to predict restenosis.
Conclusion: The use of flow rate data before and after angioplasty is helpful not only to evaluate the treatment immediately after the procedure but also to evaluate the effectiveness of the treatment during a long period. PCMRA provides a noninvasive method for measuring arterial flow rates with far-reaching implications in neurosurgery.
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BMC Cancer
January 2025
Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China.
Background: Multiple studies have demonstrated that the abundance and functionality of γδ T cells are favorable prognostic indicators for prolonged survival in cancer patients. However, the association between the immunophenotype of circulating γδ T cells and the therapeutic response in NSCLC patients undergoing chemotherapy or targeted therapy remains unclear.
Methods: Patients with EGFR wild-type (EGFR-WT) or mutant (EGFR-Mut) non-small cell lung cancer (NSCLC), diagnosed between January 2020 and January 2024, were included in this study.
Nefrologia (Engl Ed)
January 2025
Department of Ultrasound, The Second Hospital of Dalian Medical University, Dalian City, Liaoning Province, China. Electronic address:
Objective: As radiocephalic fistula is not necessarily appropriate for all patients with advanced kidney disease, our aim was to investigate the sensitive indicators that affect the functional primary patency of radiocephalic fistulas.
Methods: This prospective observational study included consecutive patients referred to the Second Hospital of Dalian Medical University for initial creation of radiocephalic fistula from July 2017 to December 2019. Preoperative ultrasound parameters, demographic characteristics, serum indicators and comorbidities were recorded.
Anal Chem
January 2025
Synthetic Molecule Design and Development, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States.
Single-stranded guide RNAs (sgRNAs) are important therapeutic modalities that facilitate selective genome editing by the CRISPR/Cas9 system. While these therapeutic modalities are synthesized through solid phase oligonucleotide synthesis similar to small interfering RNA (siRNAs) and antisense oligonucleotide (ASOs) therapeutics, their sequence length and complex secondary and tertiary structure hinder analytical characterization. The resulting current sgRNA methodologies have limited chromatographic selectivity near the FLP and limited MS compatibility.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
University of California, Berkeley─University of California, San Francisco Graduate Program in Bioengineering, San Francisco, California 94158, United States.
Neutrophil extracellular traps (NETs) are networks of decondensed chromatin, histones, and antimicrobial proteins released by neutrophils in response to an infection. NET overproduction can cause an exacerbated hyperinflammatory response in a variety of diseases and can lead to host tissue damage without clearance of infection. Nanoparticle drug delivery is a promising avenue for creating materials that can both target NETs and deliver sustained amounts of NET-degrading drugs to alleviate hyperinflammation.
View Article and Find Full Text PDFJ Neurosci Methods
January 2025
IBME, Department of Engineering Science, University of Oxford, Oxford UK.
Background: Cerebrovascular reactivity (CVR) reflects the ability of cerebral blood vessels to adjust their diameter in response to vasoactive stimuli, which is crucial for maintaining brain health. Traditional CVR assessments commonly use a two-point measurement, assuming a linear relationship between cerebral blood flow (CBF) and arterial CO. However, this approach fails to capture non-linear characteristics, particularly the plateaus at extreme CO levels.
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