The Smad family of proteins have been implicated as major components of the TGF beta signalling pathway and are important mediators of its pleiotrophic effects. Here we describe the cloning and characterization of the mink (Mustela vison) ortholog of Smad4. Mink Smad4 has a high level of conservation to its human counterpart showing 96% homology at the DNA level and 99% at the amino acid level. This is in agreement with the close homologies seen for the rat and mouse orthologs. In vitro transcription and translation shows the expression of a protein of predicted molecular weight, of identical size to its human counterpart.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/10425170290019892 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Molecular ecology of novel amdoparvoviruses and old protoparvoviruses in Spanish wild carnivorans.
Infect Genet Evol
January 2025
Instituto Agroalimentario de Aragón-IA2 (Universidad de Zaragoza-CITA), Miguel Servet 177, 50013 Zaragoza, Spain; Fundación ARAID, Zaragoza, Av. Ranillas, 1-D, 50018 Zaragoza, Spain; Facultad de Ciencias de la Vida, Universidad Andres Bello, Av. República 252, Santiago, Chile. Electronic address:
Wild carnivorans are key hosts of parvoviruses of relevance for animal health and wildlife conservation. However, the distribution and diversity of parvoviruses among wild carnivorans are under-investigated, particularly in Southern Europe. We evaluated the presence, spread, and diversity of multi-host protoparvoviruses (canine parvovirus type 2 (CPV-2), feline panleukopenia virus (FPV)), and amdoparvoviruses in 12 carnivoran species from Northern Spain to explore viral ecology.
View Article and Find Full Text PDFMorphometric parameters of blood lymphocytes in American mink (Neogale vison) selected for tameness and defensive aggression toward humans.
Tissue Cell
December 2024
Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 10 Ac. Lavrentyeva ave., Novosibirsk 630090, Russia; Novosibirsk State University, 1 Pirogova st., Novosibirsk 630090, Russia.
Although there is some evidence to suggest that there is a link between behavior and immune parameters in animals, this issue is still not well understood. In particular, there is a lack of understanding of how specific behaviors affect the size of immune cells. To address this issue, we investigated the relationship between behavior and the morphometric parameters of lymphocytes in American mink (Neogale vison) that have been selectively bred for aggression and tameness toward humans at the Institute of Cytology and Genetics in Novosibirsk, Russia, for 37 years.
View Article and Find Full Text PDFCharacterizing the gut microbiome of diarrheal mink under farmed conditions: A metagenomic analysis.
PLoS One
October 2024
College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong, China.
This study aimed to comprehensively characterize the gut microbiota in diarrheal mink. We conducted Shotgun metagenomic sequencing on samples from five groups of diarrheal mink and five groups of healthy mink. The microbiota α-diversity and Kyoto Encyclopedia of Genes and Genomes (KEGG) orthology did not show significant differences between the groups.
View Article and Find Full Text PDFCoprophenomena Associated With Worse Individual and Family Function for Youth With Tourette Syndrome: A Cross-Sectional Study.
Neurol Clin Pract
February 2025
Department of Neurology (SPM, HA, AEV, JWM, JV), University of Rochester, NY; HUCK Institute of the Life Sciences (KDM), Penn State University, State College, PA; Kennedy Krieger Institute (EA), Johns Hopkins University, Baltimore, MD; Department of Pediatrics (AC), University of Rochester, NY; and Departments of Pediatrics and Psychiatry (ABL, TKM), University of South Florida, Tampa.
Article Synopsis
- Tourette syndrome (TS) is characterized by multiple motor tics and phonic tics lasting over a year, with some youth experiencing coprophenomena (obscene tics) and more psychiatric issues compared to those without it.
- This study assessed the relationship between tic severity, co-occurring conditions, and the impact on individual and family functioning in youth with TS, focusing on those with and without coprophenomena.
- Results indicated that youth with TS and coprophenomena had significantly higher tic severity and lower scores in global function, family functioning, and parent quality of life compared to those without coprophenomena.
Exploring the impact of durvalumab on biliary tract cancer: insights from real-world clinical data.
Cancer Immunol Immunother
October 2024
Department of Internal Medicine I for Hematology With Stem Cell Transplantation, Hemostaseology, and Medical Oncology, Ordensklinikum Linz, Linz, Austria.
Article Synopsis
- This study evaluates the use of durvalumab combined with platinum and gemcitabine for treating biliary tract cancers, aiming to validate previous trial results in a real-world setting and investigate how molecular profiles may affect patient outcomes.* -
- The analysis involved 102 patients from multiple cancer centers, revealing a 71.57% disease control rate and a median overall survival of 13.61 months, with younger patients showing better outcomes.* -
- Findings indicate that while no specific molecular profiles predicted better responses to durvalumab, patients receiving tailored second-line therapy showed a potential survival advantage, highlighting the need for further research in this area.*
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!