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A deep learning analysis for dual healthcare system users and risk of opioid use disorder.
Sci Rep
January 2025
Washington DC VA Medical Center, Washington, DC, USA.
The opioid crisis has disproportionately affected U.S. veterans, leading the Veterans Health Administration to implement opioid prescribing guidelines.
View Article and Find Full Text PDFHatching of whipworm eggs induced by bacterial contact is serine-protease dependent.
PLoS Pathog
January 2025
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Whipworms (Trichuris spp) are ubiquitous parasites of humans and domestic and wild mammals that cause chronic disease, considerably impacting human and animal health. Egg hatching is a critical phase in the whipworm life cycle that marks the initiation of infection, with newly hatched larvae rapidly migrating to and invading host intestinal epithelial cells. Hatching is triggered by the host microbiota; however, the physical and chemical interactions between bacteria and whipworm eggs, as well as the bacterial and larval responses that result in the disintegration of the polar plug and larval eclosion, are not completely understood.
View Article and Find Full Text PDFVaccination coverage and its determinants in patients with multiple sclerosis-a multicenter cross-sectional study.
Ther Adv Neurol Disord
January 2025
Department of Neurology, Jena University Hospital, Am Klinikum 1, Jena 07747, Germany.
Background: Complete vaccination coverage is recommended by multiple sclerosis (MS) societies for patients with multiple sclerosis (pwMS) to mitigate infection risks associated with disease-modifying therapies (DMTs).
Objectives: To analyze vaccination coverage and its determinants in pwMS compared to healthy controls, considering vaccination hesitancy, MS-specific vaccination beliefs, trust in information sources, and the role of general practitioners (GPs).
Methods: This cross-sectional multicenter observational study was conducted in six German MS centers.
Cyclophilin A Regulates Tripartite Motif 5 Alpha Restriction of HIV-1.
Int J Mol Sci
January 2025
Clinic of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
The peptidyl-prolyl isomerase A (PPIA), also known as cyclophilin A (CYPA), is involved in multiple steps of the HIV-1 replication cycle. CYPA regulates the restriction of many host factors by interacting with the CYPA-binding loop on the HIV-1 capsid (CA) surface. TRIM5 (tripartite motif protein 5) in primates is a key species-specific restriction factor defining the HIV-1 pandemic.
View Article and Find Full Text PDFPain Reduction in Patellofemoral Knee Patients During 3-Month Intervention with Biomechanical and Sensorimotor Foot Orthoses: A Randomized Controlled Clinical Study.
Biomedicines
December 2024
Department of Sports Science, RPTU University of Kaiserslautern-Landau, 67663 Kaiserslautern, Germany.
Patellofemoral pain (PFP) significantly affects patients' daily activities and consequently reduces their quality of life. Custom-made foot orthoses (FOs) are a common method of medical treatment that positively influences biomechanical factors such as the kinematics of the lower extremity and reduces pain perception in patients. However, there is a gap in research regarding the influence of different FO treatments on knee pain.
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