Int J Dev Neurosci
Rose F. Kennedy Center for Research in Mental Retardation and Developmental Disabilities, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Published: December 2002
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http://dx.doi.org/10.1016/s0736-5748(02)00030-8 | DOI Listing |
Organometallics
October 2024
Department of Chemistry, University of Rochester, Rochester, New York 14627, United States.
The catalytic activity of an NHC-pyridonate-supported nickel(0) complex for Suzuki-Miyaura coupling of aryl halides was evaluated. Product formation was observed in the absence of a basic additive. However, low turnover numbers resulted from competitive catalyst deactivation.
View Article and Find Full Text PDFDalton Trans
December 2024
Department of Chemistry, University of Rochester, Rochester, NY 14627, USA.
The carboxamide functional group has a privileged role in organic and biological chemistry due to its prevalence and utility across synthetic and natural products. Due to n → π* delocalisation, amides and related functional groups are typically kinetically resistant to degradation. Nonetheless, over the past decade, transition metal catalysis has transformed our ability to utilise molecules featuring C(acyl)-N units as reactants.
View Article and Find Full Text PDFChem Commun (Camb)
November 2023
Department of Chemistry, University of Rochester, Rochester, NY 14627, USA.
Herein, we describe nickel-catalyzed nitrile hydroboration with pinacolborane, wherein a tethered NHC-pyridonate ligand enables efficient catalysis (5 mol% [Ni], ≤6 h reaction time) at room temperature. Mechanistic studies, including isolation of the catalytically relevant intermediates, shed light on the cooperative role of the ligand in activating both reagents simultaneously.
View Article and Find Full Text PDFJACS Au
September 2023
University of Rochester, Department of Chemistry, Rochester, New York 14627, United States.
Carboxylic acid derivatives are appealing alternatives to organohalides as cross-coupling electrophiles for fine chemical synthesis due to their prevalence in biomass and bioactive small molecules as well as their ease of preparation and handling. Within this family, carboxamides comprise a versatile electrophile class for nickel-catalyzed coupling with carbon and heteroatom nucleophiles. However, even state-of-the-art C(acyl)-N functionalization and cross-coupling reactions typically require high catalyst loadings and specific substitution patterns.
View Article and Find Full Text PDFJ Org Chem
January 2023
Department of Chemistry, University of Rochester, Rochester, New York14627, United States.
Recent theoretical work and experiments at molecular junctions have provided a strong conceptualization for the effects of oriented electric fields (OEFs) on organic reactions. Depending on the axis of application, OEFs can increase (or decrease) the reaction rate or distinguish between isomeric pathways. Despite the conceptual elegance of OEFs, which may be applied externally or induced locally, as tools for catalyzing organic reactions, implementation in synthetically relevant systems has been hampered by inefficiencies in evaluating reaction sensitivity to field effects.
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