AI Article Synopsis
- DEC-205 is a key receptor for antigen uptake and serves as a marker for dendritic cell lineage, showing about 80% structural similarity between hamsters and other species.
- The study identified the primary structure and tissue distribution of hamster DEC-205, finding it predominantly expressed in the thymus and bone marrow under specific growth factors.
- Additionally, DEC-205 is located on cell membranes and is involved in facilitating the uptake of certain proteins, indicating its critical role in the immune response across different species.
Article Abstract
DEC-205, a putative antigen uptake receptor, belongs to a family of transmembrane C-type lectins. This molecule is known to be one of the most authentic markers for the lineage of dendritic cells. In the present study, we determined the primary structure, tissue distribution and cellular localization of hamster DEC-205. The multi-domain structure of mouse and human DEC-205 was completely conserved in hamster with the overall identity of approximately 80%. DEC-205 transcripts were detected in the thymus and bone marrow cells cultured in the presence of mouse granulocyte macrophage colony-stimulating factor and interleukin-4 in which the DEC-205 expression was up-regulated in the course of cultures. Hamster DEC-205 was mainly detected on cell membrane and shown to mediate the uptake of flourescein isothiocyanate-conjugated ovalbumin. DEC-205 is a highly conserved molecule across the species suggesting its fundamental role in the immune system.
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| http://dx.doi.org/10.1016/s0304-3835(02)00067-8 | DOI Listing |
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