In a concluding session, David Knight (University of Durham) took the title '"One great slaughter-house the warring world"--living in revolutionary times'. He pointed out that Darwinian thought had to contend with three revolutions. First, the political revolutions of 1776 and 1789, leading to the terror of the 1790s that washed over the English Midlands leaving Priesley's house burnt and Priestley himself exiled to America. Second, the scientific revolution, which valued exact knowledge and specialism rather than wide syntheses. Third, the Romantic revolution which emphasized the tragic rather than the cheerful optimism of Darwin's heroic couplets. For all these reasons Darwin's influence waned. However, Knight finished on an optimistic note that echoed King-Hele's opening address, saying that in our own times, as suspicion of experts grows, and some, at least, see science as a liberating force, Darwin's fame may recover. Negotiations are in process for the publication of the proceedings under the title 'The genius of Erasmus Darwin: proceedings of a bicentennial conference', and a website has been constructed that contains details of all speakers (http://www.bham.ac.uk/erasmusdarwin/).
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Pharmacoepidemiol Drug Saf
November 2024
Pharmaco- and Device Epidemiology, Centre for Statistics in Medicines, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Purpose: The generation of representative disease phenotypes is important for ensuring the reliability of the findings of observational studies. The aim of this manuscript is to outline a reproducible framework for reliable and traceable phenotype generation based on real world data for use in the Data Analysis and Real-World Interrogation Network (DARWIN EU). We illustrate the use of this framework by generating phenotypes for two diseases: pancreatic cancer and systemic lupus erythematosus (SLE).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge, UK.
Introduction: Genetic mutation carriers of frontotemporal dementia can remain cognitively well despite neurodegeneration. A better understanding of brain structural, perfusion, and functional patterns in the pre-symptomatic stage could inform accurate staging and potential mechanisms.
Methods: We included 207 pre-symptomatic genetic mutation carriers and 188 relatives without mutations.
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