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Syntheses of Metal Phthalocyanines and Their Photoinactivations on Cancer Cells. | LitMetric

Syntheses of Metal Phthalocyanines and Their Photoinactivations on Cancer Cells.

Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai)

Department of Chemistry, Institute of Functional Materials, Fuzhou University, Fuzhou 350002, China.

Published: January 1998

This paper reported the syntheses of amphiphilic substituted metal phthalocyanines containig sulfonic acid groups and phthalimidomethyl groups (MPcSP, M=Zn or Al(OH), S=-SO(3)(-), P=phthalimidomethyl). We have selected zinc phthalocyanine (Zn-D) as the one with better cell killing potential by an in vitro cell survival assay. Over 90 % tumor cells were killed with 10 mg/L Zn-D, after they were exposed to 12 J/cm(2) red light.

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