[Peripheral blood lymphocyte metabolism in schizophrenic patients].

The lymphocytes in the peripheral blood of schizophrenic patients and normals were parallelly studied for the concentration of pyruvic and lactic acid, LDH activity an succinatedehydrogenase, glutamatoxalate and glutamate-pyruvattransaminase. It was established that in the cells of schizophrenic patients compared to normals there was an increased concentration of pyruvic acid, while the LDH activity was decreased. The remaining indices did not differ from normals. The achieved data permit to assume that the accumulation of pyruvic acid in the lymphocytes of schizophrenic patients is due to a drop of the LDH activity in the cells. The oxydative transition of pyruvic acid, as well as the processes of transamination play an insignificant role in the metabolism of these cells.