Background: Owing to their various advantages, including shortened hospital stays, faster recoveries, and satisfactory outcomes, laparoscopic bladder neck suspension (LBNS) and tension-free vaginal tape (TVT) have become 2 well-known minimally-invasive anti-incontinent procedures. The aim of this study was to demonstrate the outcomes of LBNS and TVT procedures for treatment of stress urinary incontinence.
Methods: From October 1997 to February 2000, 22 women with genuine stress incontinence underwent LBNS, and another 23 women underwent TVT. Estimates of operative time, blood loss, and time to resumption of spontaneous urination were recorded for each group. Surgical results were assessed by urodynamic studies, 1-h pad tests, and voiding diaries.
Results: There were no statistically significant differences between these 2 groups in terms of demographics and blood loss during the operation. When comparing operative time and time to resumption of spontaneous urination, the TVT group had significantly lower values than did the LBNS group for both parameters, at 31.9+/-6.0 vs. 111.7+/-15.6 min and 2.1+/-1.5 vs. 4.0+/-0.9 days, respectively. The cure rate was 86.9% in the TVT group and 86.4% in the LBNS group.
Conclusion: Both TVT and LBNS have been proven effective in treating women with stress urinary incontinence. The TVT procedure, owing to its shorter learning curve, less intraoperative blood loss, and quicker resumption of spontaneous urination, is recommended to treat women suffering from pure stress urinary incontinence. Whereas, in cases that are complicated with concomitant adnexal disease or uterine pathology, LBNS is considered an alternative procedure.
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JPEN J Parenter Enteral Nutr
January 2025
The University of Queensland, Brisbane, Australia.
Background: Advanced glycation end-products (AGEs) can enter patients' circulation through exogenous sources, such as enteral nutrition formulae. Circulating AGEs, specifically carboxymethyllysine, can promote insulin resistance and activation of pro-inflammatory pathways leading to oxidative stress, cell death, and organ failure. Suboptimal kidney function increases the risk of elevated circulating AGEs because levels are controlled through urinary excretion.
View Article and Find Full Text PDFJ Trace Elem Med Biol
January 2025
College of Life Sciences, Anhui Normal University, Wuhu, Anhui 241000, China.
Background: Cadmium (Cd) is a toxic heavy metal present in environment that has potential to instigate renal toxicity. Didymin (DDM) is a natural flavone, which shows anti-oxidant, anti-inflammatory and antiapoptotic nature. Therefore, the current study was formulated to appraise attenuative potential of DDM against Cd instigated nephrotoxicity.
View Article and Find Full Text PDFFASEB J
January 2025
Department of Medicine, Hematology and Oncology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Nuclear factor of activated T-cells 5 (NFAT5) is a transcription factor known for its role in osmotic stress adaptation in the renal inner medulla, due to the osmotic gradient that is generated between the renal cortex and renal inner medulla. However, its broader implications in kidney injury and chronic kidney disease (CKD) are less understood. Here we used two different Cre deleter mice (Ksp1.
View Article and Find Full Text PDFInt Urogynecol J
January 2025
Division of Health Services Research & Implementation Science, Southern California Permanente Medical Group, San Diego, CA, USA.
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Methods: A narrative review was conducted by an international, multi-disciplinary group of clinicians working in the field of pelvic health following a search of the literature using the MeSH terms "pelvic organ prolapse" OR "urogenital prolapse" OR "vaginal prolapse" OR "uterovaginal prolapse" AND "pessary" OR "support device" OR "intravaginal device." Relevant studies, as determined after review using the Covidence manuscript review platform, were included.
Front Med (Lausanne)
January 2025
Beilun District People's Hospital, Beilun Branch of the First Affiliated Hospital of Zhejiang University, Ningbo, China.
Background: Stress urinary incontinence (SUI) is involuntary urine leakage during effort. Pelvic floor muscle training (PFMT) is a common physical therapy for SUI, but has low adherence and its long-term effectiveness is uncertain. Drug therapy has side-effect problems and surgery has risks.
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