Protein fractions were prepared from placental tissue by homogenization, ammonium sulfate fractionation, gel filtration and ion exchange chromatography. The antigens detected in these fractions by absorbed antisera against placental tissue and pregnancy serum partly occur in the pregnancy and fetal serum too. The other antigens, which are found neither in pregnancy serum nor in fetal serum, could be specific for placental tissue. Their possible significance is discussed.
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