AI Article Synopsis
- The study aimed to assess changes in retinal blood vessels over pigment epithelial detachments (PED) in patients with exudative age-related macular degeneration (ARMD) using specialized imaging techniques.
- Out of 41 patients examined, significantly more vascular abnormalities were detected with indocyanine green angiography compared to fluorescein angiography, indicating its greater sensitivity.
- A correlation was found between retinal vasculopathy, choroidal neovascularizations, and the size of the PED, suggesting potential implications for understanding disease progression in ARMD.
Article Abstract
Purpose: To evaluate alterations in the retinal vasculature overlying pigment epithelial detachments (PED) in exudative age-related macular degeneration (ARMD) using indocyanine green and fluorescein angiography.
Methods: Forty-one patients (41 eyes) with a clinical diagnosis of exudative ARMD with PED underwent simultaneous fluorescein and indocyanine green angiography, also under high (10 degrees ) magnification. Vascular abnormalities in the retina were compared between patients with vascularized (n = 34, group 1) and nonvascularized (n = 7, group 2) PED on indocyanine green angiography and correlated with the size of the PED and the presence of serous retinal detachment.
Results: In all, 67 vascular abnormalities were found by indocyanine green angiography and only 22 by fluorescein angiography; this finding was statistically significant (P < 0.0001). The finding of retinal vasculopathy (32 patients in group 1 and two patients in group 2) was directly correlated with the presence of choroidal neovascularizations (P = 0.002). There was also a direct correlation between the presence of choroidal neovascularization and size of the PED (P = 0.03). The number of retinal vascular findings was not significantly correlated with serous elevation of the retina.
Conclusions: Retinal vasculopathies may be observed in eyes with PED and are detectable by indocyanine green and fluorescein angiography.
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| http://dx.doi.org/10.1097/00006982-200208000-00002 | DOI Listing |
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