Synthesis of the kappa-agonist CJ-15,161 via a palladium-catalyzed cross-coupling reaction.

Chem Commun (Camb)

Chemical Research and Development, Pfizer Global Research and Development, Eastern Point Road, P.O. Box 8013, Groton, CT 06340-8013, USA.

Published: August 2002

Syntheses of CJ-15,161 (1) involving intermolecular N-arylation of an appropriately functionalized diamine, obtained from the precursor alpha-amino acids or, more conveniently, from the corresponding 1,2-amino alcohols via 1,2,3-oxathiazolidine-2,2-dioxide 22, are reported.

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Source
http://dx.doi.org/10.1039/b204844bDOI Listing

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