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Bibliometric analysis of laryngeal cancer treatment literature (2003-2023).
Heliyon
January 2025
Department of Otolaryngology Head and Neck Surgery, the Second People's Hospital of Shenzhen, the First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong Province, 518035, China.
Background: Despite advancements in medical science, the 5-year survival rate for laryngeal squamous cell carcinoma remains low, posing significant challenges in clinical management. This study explores the evolution of key topics and trends in laryngeal cancer research. Bibliometric and knowledge graph analysis are utilized to assess contributions in treating this carcinoma and to forecast emerging research hotspots that may enhance future clinical outcomes.
View Article and Find Full Text PDFLongitudinal Assessment of Structural and Functional Changes in Rod-cone Dystrophy: A 10-year Follow-up Study.
Ophthalmol Sci
November 2024
Faculty of Medicine, Dentistry and Health Sciences, Department of Optometry and Vision Sciences, University of Melbourne, Parkville, Australia.
Purpose: Emerging clinical trials for inherited retinal disease (IRD) require an understanding of long-term progression. This longitudinal study investigated the genetic diagnosis and change in retinal structure and function over 10 years in rod-cone dystrophies (RCDs).
Design: Longitudinal observational follow-up study.
Purpose: To describe progression of best-corrected visual acuity (BCVA), full-field stimulus thresholds (FST), and electroretinography (ERG) over 4 years in the -related Retinal Degeneration study and to assess their suitability as clinical trial endpoints.
Design: Prospective natural history study.
Participants: Participants (n = 105) with biallelic disease-causing sequence variants in USH2A and BCVA letter scores of ≥54 were included.
Recent Advances in Asymmetric Wettability Dressings for Wound Exudate Management.
Research (Wash D C)
January 2025
School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, P. R. China.
The management of wound exudate is of vital importance for wound healing. Exudate accumulation around wound prolongs inflammation and hinders healing. Although traditional dressings can absorb wound exudate, they are unable to drain exudate in time, often resulting in a poor feature with wound healing.
View Article and Find Full Text PDFRecent progress in the organoselenium-catalyzed difunctionalization of alkenes.
Org Biomol Chem
January 2025
School of Pharmacy, Nantong Key Laboratory of Small Molecular Drug Innovation and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226019, People's Republic of China.
Selenium-based catalysts have recently been utilized to facilitate a variety of new organic transformations, owing to their intrinsic advantages, including low cost, low toxicity, stability in both air and water, and strong compatibility with diverse functional groups. The difunctionalization of alkenes-the process of incorporating two functional groups onto a carbon-carbon double bond-has garnered particular interest within the chemical community owing to its significant applications in organic synthesis. Recently, organoselenium-catalyzed difunctionalization of alkenes has emerged as an ideal and powerful route to obtain high-value vicinal difunctionalized molecules.
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