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Low-molecular-weight dextran-induced anaphylactic shock immediately after intracoronary imaging.
J Cardiol Cases
September 2022
Department of Cardiovascular Medicine, Division of Medicine, Biomedical Sciences Major, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Unlabelled: Dextran has been frequently used during intracoronary imaging, such as in optical coherence tomography, optical frequent domain imaging, and coronary angioscopy. We report a case of dextran-induced anaphylaxis in a 70-year-old male with chronic coronary disease. Upon admission, we performed coronary angiography and coronary angioscopy on the patient.
View Article and Find Full Text PDFSafety of dextran in relation to other colloids--ten years experience with hapten inhibition.
Infusionsther Transfusionsmed
October 1993
Department of Surgery, Karolinska Institutet, Danderyd Hospital, Sweden.
Objective: The effects of hapten inhibition with dextran 1 (molecular weight: 1,000 D, Promit), which is in use since 1982 for the prevention of severe dextran-induced anaphylactic reactions (DIAR) caused by immune complexes, were studied.
Design: Spontaneous reports to the manufacturer and to the WHO database INTDIS regarding adverse reactions to clinical dextran after preinjection of dextran 1 and to dextran 1 alone were collected from 1983 to 1992. During this period a total of 5.
Histopathological lung changes in immune complex mediated anaphylactic shock in humans elicited by dextran.
Forensic Sci Int
September 1988
Department of Surgery, Karolinska Institute, Danderyd Hospital, Sweden.
Severe dextran-induced anaphylactic reaction (DIAR) is being recognized as a form of immediate IgG mediated immune complex reaction. Support for this pathogenesis is found in the correlation between the titer of dextran-reactive antibodies of IgG class and the severity of the reaction. Autopsy records were reviewed in 27 certified cases of fatal DIAR.
View Article and Find Full Text PDFSuccessful percutaneous transluminal coronary angioplasty is achieved by fracture of the atheromatous plaque and perhaps dilatation of the arterial walls to increase the luminal diameter of the artery. Because this "controlled" injury stimulates platelet adhesion on the subendothelial matrix, the use of dextran-40 in addition to heparin has been advocated. The overall incidence of Dextran-induced anaphylactoid reactions at our institution was 0.
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