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Targeting cholesterol-dependent adrenal steroidogenesis for management of primary aldosteronism.
Trends Endocrinol Metab
January 2025
Department of Hypertension and Endocrinology, Center for Hypertension and Metabolic Diseases, Daping Hospital, Army Medical University, Chongqing Institute of Hypertension, Chongqing, China; Chongqing Institute for Brain and Intelligence, Chongqing, China. Electronic address:
Primary aldosteronism (PA) is a common, salt-sensitive form of endocrine hypertension. Compared with essential hypertension (EH), PA is more susceptible to cardiorenal complications and metabolic risks. However, PA has a low screening rate and a poor response to mineralocorticoid receptor antagonists (MRAs).
View Article and Find Full Text PDFA 21st-century update of Claude Bernard's Theory about the Constancy of the Internal Environment.
Neuropsychopharmacol Hung
December 2024
Municipal Clinic of Szentendre, Internal Medicine, Szentendre, Hungary.
Article Synopsis
- The understanding of ion compartments and cell membrane functions leads to insights into intracellular ions and their roles in health, especially concerning the regulation of carbon dioxide levels as a vital signaling molecule.
- Chronic stress alters ion patterns, influencing conditions like Metabolic Syndrome and mental disorders, highlighting the connection between ion balance and overall health.
- To maintain well-being and potentially extend lifespan, it's crucial to preserve the original ion pattern through proper ventilation and possibly the administration of specific ion salts.
High Salt Exacerbates Myocardial Dysfunction In Vitro and In Vivo by Promoting SIRT1/Nrf2-Mediated Ferroptosis.
Clin Exp Pharmacol Physiol
February 2025
Department of Nephropathy, Xi'an Central Hospital, Xi'an, China.
Myocardial dysfunction is a crucial determinant of the development of heart failure in salt-sensitive hypertension. Ferroptosis, a programmed iron-dependent cell death, has been increasingly recognised as an important contributor to the pathophysiology of various cardiovascular diseases. This study aims to investigate the role and underlying mechanism of ferroptosis in high-salt (HS)-induced myocardial damage.
View Article and Find Full Text PDFPossible involvement of up-regulated salt-dependent glucose transporter-5 (SGLT5) in high-fructose diet-induced hypertension.
Hypertens Res
December 2024
Department of Nephrology and Hypertension, Saitama Medical Center, Saitama Medical University, Kamoda 1981, Kawagoe, Saitama, 350-8550, Japan.
Excessive fructose intake causes a variety of adverse conditions (e.g., obesity, hepatic steatosis, insulin resistance and uric acid overproduction).
View Article and Find Full Text PDFIncreased Salt Sensitive Blood Pressure in Women Versus men: Is Relative Hyperaldosteronism the Mechanism?
J Clin Endocrinol Metab
December 2024
Division of Endocrinology, Diabetes and Hypertension, Harvard Medical School, Brigham and Women's Hospital, 221 Longwood Avenue, RFB-2, Boston, MA, 02115, USA.
Context: Women versus men have more Salt sensitive blood pressure (SSBP) and higher stimulated aldosterone (ALDO) levels, suggesting that their increased SSBP is secondary to a relative hyper-ALDO state. Contrariwise, men versus women have higher sedentary ALDO levels.
Objective: Thus, the present project was designed to address the question are women versus men in a relatively hyper-ALDO state?
Methods: 363 women, and 483 men were selected from HyperPATH cohort to assess the potential underlying mechanism for observed sex differences.
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