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From Theory to Therapy: Unlocking the Potential of Muscarinic Receptor Activation in Schizophrenia With the Dual M1/M4 Muscarinic Receptor Agonist Xanomeline and Trospium Chloride and Insights From Clinical Trials.
Int J Neuropsychopharmacol
March 2025
Bristol Myers Squibb, Princeton, NJ, United States.
Since the 1950s, understanding of antipsychotic activity in schizophrenia has been largely grounded in the dopamine hypothesis. Most antipsychotics approved for schizophrenia interact with D2 dopamine receptors as an important part of their mechanism of action. While antipsychotics blocking D2 dopamine receptors can be effective for positive symptoms of schizophrenia, none are approved by regulatory authorities for predominant negative or cognitive symptoms.
View Article and Find Full Text PDFLiver injury in tuberculosis patients, associated with noncompliance with treatment, is further exacerbated by viral hepatitis, which not only directly harms the liver but also increases susceptibility to drug-induced liver injury. The aim of this study was to analyze the associated risk factors for viral hepatitis in tuberculosis patients. This systematic review and meta-analysis adhere to the PRISMA 2020 statement, and the protocol has been registered with PROSPERO (CRD42023477241).
View Article and Find Full Text PDFProteomic identification of a sporozoite-specific antigen using HDAC3 inhibitor-treated tachyzoites as surrogate.
FEMS Microbes
December 2024
FG16: Mycotic and Parasitic Agents and Mycobacteria, Robert Koch Institute, 13353 Berlin, Germany.
Article Synopsis
- The apicomplexan parasite has a complicated life cycle that includes less accessible stages, requiring animal experiments, specifically with cats, for study.
- Recent research identified key factors that trigger the parasite's differentiation, and inhibiting a specific enzyme (HDAC3) can lead to the expression of genes tied to sexual stages and oocysts.
- By using the HDAC3 inhibitor apicidin, researchers discovered the sporozoite-specific antigen SporoSAG and enhanced the detection of another protein, LEA860, allowing for the study of these stages without needing materials derived from cats.
The assessment and aetiology of drug-induced ischaemic priapism.
Int J Impot Res
December 2024
Associate Professor in the Division of Urology, Department of Surgery, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Ischaemic priapism is a urological emergency characterised by a prolonged, painful erection unrelated to sexual stimulation. While several aetiological factors contribute to this condition, the pharmacological causes have gained significant attention in recent years. This narrative review aims to comprehensively assess ischaemic priapism, specifically focusing on its pharmacological aetiology.
View Article and Find Full Text PDFPsychotropic drug-induced adverse drug reactions in 462,661 psychiatric inpatients in relation to age: results from a German drug surveillance program from 1993-2016.
Ann Gen Psychiatry
November 2024
Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany.
Background: Clinical practice suggests that older adults (i.e., ≥ 65 years of age) experience adverse drug reactions (ADRs) more often than younger patients (i.
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