Genetic deficiencies of nearly all of the 30 complement system proteins have been recognized clinically. In many instances, the molecular basis for the deficiency has been elucidated. As a byproduct of these studies, we now have new insights into the pathophysiologic role of complement studies in several acquired diseases. New targets for drug development are among the practical outcomes of work on complement genetics.
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| http://dx.doi.org/10.1007/s11882-002-0070-6 | DOI Listing |
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