Objective: Our aim was to perform a comparative study between IVP (Intra Venous Pyelography) and Doppler US (Ultras Sound) in assessing the normal renal function. The US assessment of the normal renal function consisted in the evaluation of ureteral flux.
Materials And Methods: The group of patients consisted in 79 patients with small size urinary stones (5-12 mm). Among them, 58 patients had pelvic stones and 21 patients had ureteral stones. The ultrasound system used in our study was a B&K Medical Panther 2002 equipped with a 3.5 MHz transducer.
Results: The sensibility in detecting ureteral flux in patients with pelvic stones and normal IVP was 100%. The sensibility in detecting uretheral flux in ureteral stones with IVP aspect of hydronephrosis was 65%.
Conclusions: In cases of normal aspect of IVP the presence of uretheral flux assessed by ultrasound could substitute the IVP in the preoperative evaluation for ESWL treatment. In cases of hydronephrotic aspect of IVP, the concordance between results based on IVP and those based on Doppler US in good enough for proposing the Doppler US evaluation of renal function in obstructive stones as a new diagnostic imaging modality. Doppler US could be the method of choice for renal function pre ESWL evaluation mainly for patients with known intolerance to contrast media.
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Pediatr Nephrol
January 2025
Department of General Pediatrics, Pediatric Nephrology, University Hospital Münster, Münster, Germany.
Nano Lett
January 2025
NMR Signal Enhancement Group, Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany.
Deuterium (H) MRI is an emerging tool for noninvasive imaging. We explore the integration of H MRI with deuterated multifunctional nanopolymers for deuterated particle imaging (DPI). To this end, amine-terminated G5-polyamidoamine (PAMAM) dendrimers were labeled with deuterated acetyl surface groups, leading to highly H-loaded bioparticles, making them ideal for imaging studies.
View Article and Find Full Text PDFBr J Clin Pharmacol
January 2025
Department of Medical Microbiology, Haaglanden Medisch Centrum, The Hague, The Netherlands.
Aims: The beta-lactam antibiotic temocillin is increasingly used to treat extended-spectrum beta-lactamase (ESBL-producing) strains; however, its protein binding is complex. This study aims to predict unbound temocillin concentrations in various participant groups to determine its impact on the probability of target attainment (PTA) and to improve dosing recommendations.
Methods: The plasma pharmacokinetics were analysed using non-linear mixed-effects modelling.
J Biophotonics
January 2025
State Key Laboratory of Extreme Photonics and Instrumentations, Centre for Optical and Electromagnetic Research, College of Optical Science and Engineering, International Research Center for Advanced Photonics, Zhejiang University, Hangzhou, China.
Three-photon fluorescence (3PF) microscopy encounters significant challenges in biological research and clinical applications, primarily due to the limited availability of high-performance probes. We took a shortcut by exploring the excellent 3PF property of berberine hydrochloride (BH), a clinically utilized drug derived from the traditional Chinese medicine, Coptis. Capitalizing on its renal metabolism characteristics, we employed BH for in vivo 3PF microscopic imaging of the mouse kidney.
View Article and Find Full Text PDFCirc Res
January 2025
Hypertension Research Laboratory, School of Biological Sciences (R.R.M., T.Z., E.D., L.X., A.B.-W., H.A.J., M.N., M.P., K.C.L., W.Q., J.A.O.D., F.Z.M.).
Background: Fermentation of dietary fiber by the gut microbiota leads to the production of metabolites called short-chain fatty acids, which lower blood pressure and exert cardioprotective effects. Short-chain fatty acids activate host signaling responses via the functionally redundant receptors GPR41 and GPR43, which are highly expressed by immune cells. Whether and how these receptors protect against hypertension or mediate the cardioprotective effects of dietary fiber remains unknown.
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