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Tuberculous osteo-arthritis unmasked through unusual elbow swelling: A case report.
Int J Surg Case Rep
December 2024
University of Tunis El Manar, Tunis Faculty of Medicine, 1007, Tunisia; Department of Orthopedic Surgery, Hospital Mongi Slim La Marsa, Tunisia.
Introduction And Importance: Tuberculous osteoarthritis, a rare condition affecting the elbow in 1-5 % of cases, poses diagnostic challenges due to its subtle clinical presentation, often resulting in delayed diagnosis. Herein, we present a case of tuberculous osteoarthritis involving the elbow joint. Our aim is to underscore the complexities associated with diagnosing this condition and to emphasize the critical importance of early recognition and appropriate management strategies for optimal patient outcomes.
View Article and Find Full Text PDFAlternative Management Approach for Infected Gap Non-Union of Both Bone Forearm - A Case Report.
J Orthop Case Rep
December 2024
Department of Orthopaedics, All India Institute of Medical Sciences, Guntur, Andhra Pradesh, India.
Introduction: Infected gap non-union is a serious complication seen in cases of diaphyseal fracture of forearm bones. It carries high morbidity in the form of severe functional impairment and poses a challenge to treat due to the complex anatomical relationship and articulations involved. Though there are multiple treatment options available, there are no guidelines for its management.
View Article and Find Full Text PDFSulforaphane inhibits multiple myeloma cell-induced osteoclast differentiation and macrophage proliferation by elevating ferroportin1.
Cancer Chemother Pharmacol
December 2024
Hunan Engineering Research Center for Early Diagnosis and Treatment of Liver Cancer, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Purpose: Osteolysis is a common complication in patients with multiple myeloma (MM). Our previous studies have demonstrated that MM cells can promote osteoclast differentiation of macrophages. In this study, we explored the effect of sulforaphane (SFN), a natural NRF2 activator found in broccoli, on MM cell-induced osteoclast differentiation.
View Article and Find Full Text PDFAlterations in Small Non-coding MicroRNAs (miRNAs) and the Potential Role in the Development of Aseptic Loosening After Total Hip Replacement: Study Protocol for an Observational, Cross-Sectional Study.
Cureus
October 2024
Department of Medical Physics, School of Medicine, University of Patras, Patras, GRC.
Article Synopsis
- Total hip arthroplasty (THA) is a highly successful surgery for hip osteoarthritis, but complications like aseptic loosening (AL) and periprosthetic osteolysis (PPOL) are common and account for nearly half of revision surgeries.
- This study will involve 63 patients divided into three groups to investigate alterations in specific miRNAs that might be linked to the development of AL and PPOL after THA.
- The aim is to identify inflammation-related miRNAs as potential biomarkers to better understand and predict complications in patients after hip surgery.
Multicenter Randomized Clinical Trial of Highly Cross-Linked Polyethylene Versus Conventional Polyethylene in 518 Primary TKAs at 10 Years.
J Bone Joint Surg Am
November 2024
Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota.
Background: Second-generation highly cross-linked polyethylene (HXLPE) has revolutionized total hip arthroplasty. However, the long-term risks and benefits of HXLPE in primary total knee arthroplasty (TKA) remain unknown. This randomized clinical trial evaluated implant survivorship, complications, radiographic results, and clinical outcomes of HXLPE and conventional ultra-high molecular weight polyethylene (UHMWPE) inserts in primary TKAs.
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