The asymmetric unit of the title compound, C(22)H(31)N(3)O(4).H(2)O, incorporates one water molecule, which is hydrogen bonded to the 3-oxo O atom of the indolizidinone system. The two rings of the peptidomimetic molecule are trans-fused, with the six-membered ring having a slightly distorted half-chair conformation and the five-membered ring having a perfect envelope conformation. The structure is stabilized by intermolecular O-H...O interactions between the water and adjacent peptide molecules, and by N-H...O interactions between the peptide molecules, which link the molecules into infinite chains.
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http://dx.doi.org/10.1107/s0108270102011538 | DOI Listing |
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