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Neutrophil Extracellular Traps: Potential Thrombotic Markers and Therapeutic Targets in Colorectal Cancer.
J Leukoc Biol
October 2024
Department of Medical Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.
Neutrophil extracellular traps (NETs) are promising promoters in venous thromboembolism (VTE). In the present study, we have investigated the potential thrombogenic role of NETs in colorectal cancer (CRC). A total of 583 patients with gastrointestinal malignancies who were diagnosed with or without VTE by extremities arteriovenous ultrasound and computed tomography were enrolled.
View Article and Find Full Text PDFA single-center study of reference intervals for TAT, PIC, TM and t-PAIC in healthy older Chinese adults.
Thromb J
September 2024
Department of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, No.2 Anzhen Road, Beijing, China.
Objective: To explore the distribution of thrombin-antithrombin complex (TAT), plasmin-α2-antiplasmin inhibitor complex (PIC), thrombomodulin (TM), and tissue plasminogen activator-inhibitor complex (t-PAIC) in healthy older Chinese adults, and establish the reference intervals (RIs).
Methods: The Biotech Shine i2900 chemiluminescence immune assay was used to measure the plasma concentrations of TAT, PIC, TM, and t-PAIC in 1628 adults ≥ 60 years. The RIs were established using the 2.
Fibrinolysis biomarker, thrombin, and activated protein C level alterations after coagulation activation depend on type of thrombophilia and clinical phenotype.
Res Pract Thromb Haemost
February 2024
Institute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, Bonn, Germany.
Background: Recently, we have shown alterations in the anticoagulant response to recombinant activated factor VII (rFVIIa)-induced coagulation activation in patients with thrombophilia.
Objectives: This study aimed to extend this model to fibrinolysis biomarkers.
Methods: This interventional study included 56 patients with thrombophilia and previous venous thromboembolism (VTE+), 38 without VTE (VTE-), and 35 healthy controls.
Low factor XIII levels and altered fibrinolysis in patients with multiple myeloma.
Thromb Res
February 2024
Department of Laboratory Medicine, Faculty of Medicine, Division of Clinical Laboratory Sciences, University of Debrecen, Debrecen, Hungary; Hungarian Research Network (HUN-REN-DE) Cerebrovascular Research Group, Debrecen, Hungary. Electronic address:
Article Synopsis
- Acquired factor FXIII deficiency can be linked to multiple myeloma (MM) and may lead to severe bleeding, but its prevalence and reasons are not well known.
- A study compared FXIII levels and the balance of coagulation and fibrinolysis in untreated MM and monoclonal gammopathy of undetermined significance (MGUS) patients against healthy controls, finding significant differences.
- Results indicated that MM patients exhibited lower FXIII levels due to consumption, alongside markers of hypercoagulability and ongoing fibrinolysis, suggesting disturbed hemostasis even in MGUS patients.
Validation of the time to attain maximal clot amplitude after reaching maximal clot formation velocity parameter as a measure of fibrinolysis using rotational thromboelastometry and its application in the assessment of fibrinolytic resistance in septic patients: a prospective observational study: communication from the ISTH SSC Subcommittee on Fibrinolysis.
J Thromb Haemost
April 2024
Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Department of Anesthesia and Intensive Care III, Fundeni Clinical Institute, Bucharest, Romania.
Background: In sepsis, fibrinolysis resistance correlates with worse outcomes. Practically, rotational thromboelastometry (ROTEM) is used to report residual clot amplitude relative to maximum amplitude at specified times after clot formation clot lysis indices (CLIs). However, healthy individuals can exhibit similar CLIs, thus making it challenging to solely diagnose the low fibrinolytic state.
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