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Biomarkers.
Alzheimers Dement
December 2024
The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Israel.
Background: Amyloid beta (Aβ) deposition marks an early stage in the progression of Alzheimer's disease (AD), detectable in-vivo years before symptoms emerge and targeted by recently FDA-approved drugs. This has propelled advancements in understanding, measuring, and treating AD, paving the way for disease prevention in those at risk. However, the psychological impact of disclosing Aβ status to cognitively unimpaired individuals remains underexplored.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Neurophysiology & Behaviour Lab, University of Castilla-La Mancha, Ciudad Real, Spain.
Background: A key neuropathological feature in the early stages of Alzheimer's disease (AD) involves hippocampal dysfunction arising from the accumulation of amyloid-β (Aβ). Previously, our laboratory identified a shift in the synaptic plasticity long term potentiation (LTP)/long term depression (LTD) induction threshold, leading to memory deficits in a non-transgenic murine model of early AD generated by intracerebroventricular (icv.) injections Aβ oligomers (oAβ), one of the most predominant pathogenetic factors in initial stages of the disease.
View Article and Find Full Text PDFBackground: Recent advancements in automatic language and speech analysis, coupled with machine learning (ML) methods, showcase the effectiveness of digital biomarkers in non-invasively detecting subtle changes in cognitive status. While successfully distinguishing between Alzheimer's Disease (AD) and Normal Control (NC) individuals, classifying Mild Cognitive Impairment (MCI) proves to be a more challenging task. MCI can progress to AD or result from various factors, including affective disorders, necessitating multiple expert examinations for accurate detection.
View Article and Find Full Text PDFBackground: Dementia is a major public health problem affecting millions of people worldwide. Early diagnosis and intervention are essential to improve quality of life and reduce the burden of dementia. Recently, voice digital biomarkers have emerged as a promising approach for the early detection of dementia owing to its clinical utility and accessibility.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, TAS, Australia.
Background: Finding low-cost, accessible methods to detect people with early-stage Alzheimer's disease is a research priority for neuroprotective drug development. Subtle motor impairment of gait occurs years before episodic memory decline but there has been little investigation of whether self-administered hand motor tests can detect this pre-symptomatic period. This study evaluated how home-based unsupervised keyboard tapping tests from the TAS Test protocol predict episodic memory performance in a sample of older adults without overt cognitive impairment, as a potential indicative measure of early Alzheimer's disease.
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