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Socioeconomic status mediates and modifies racial and ethnic disparities in incisional glaucoma surgical outcomes.
Am J Ophthalmol
March 2025
Department of Ophthalmology, Stein and Doheny Eye Institutes, David Geffen School of Medicine at UCLA, Los Angeles, California, USA; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA. Electronic address:
Purpose: To estimate the proportion of racial and ethnic disparities observed in glaucoma surgical outcomes that can be eliminated by curbing differences in socioeconomic status (SES).
Design: Retrospective cohort study.
Subjects: The entire population of 2016-2018 California (CA) fee-for-service Medicare beneficiaries with a claim for incisional glaucoma surgery (trabeculectomy, tube shunt, or EX-PRESS shunt).
Eye Sustainability here and now.
Asia Pac J Ophthalmol (Phila)
March 2025
Vienna Institute for Research in Ocular Surgery, A Karl Landsteiner Institute, Hanusch Hospital, Vienna, Austria.
Excitatory and inhibitory neurotransmitter alterations with advancing age and injury in the mouse retina.
Neurobiol Aging
March 2025
Neuroscience and Behavioural Diseases and Eye-ACP, SERI/SNEC, Centre for Vision Research, Duke-NUS Medical School, 8 College Road, 169857, Singapore; Save Sight Institute, University of Sydney, Sydney, NSW, Australia. Electronic address:
Increasing age and elevated intraocular pressure (IOP) are the two major risk factors for glaucoma, the most common cause of irreversible blindness worldwide. Accumulating evidence is pointing to metabolic failure predisposing to neuronal loss with advancing age and IOP injury. Many neurotransmitters are synthesized from endogenous metabolites and are essential for correct cell to cell signaling along the visual pathways.
View Article and Find Full Text PDFEffect of Customized Corneal Crosslinking on Patients With Pellucid Marginal Degeneration.
Cornea
March 2025
Department of Ophthalmology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Purpose: To evaluate the effect of customized corneal crosslinking on pellucid marginal degeneration (PMD).
Methods: Twenty-eight eyes with PMD were included. Fifteen eyes were treated with customized corneal crosslinking at Helsinki University Eye Hospital.
Dual-filament regulation of relaxation in mammalian fast skeletal muscle.
Proc Natl Acad Sci U S A
March 2025
Randall Centre for Cell and Molecular Biophysics and British Heart Foundation Centre of Research Excellence, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, United Kingdom.
Muscle contraction is driven by myosin motors from the thick filaments pulling on the actin-containing thin filaments of the sarcomere, and it is regulated by structural changes in both filaments. Thin filaments are activated by an increase in intracellular calcium concentration [Ca] and by myosin binding to actin. Thick filaments are activated by direct sensing of the filament load.
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