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Exploring auxiliary liver transplantation in the era of transplant oncology - A proposal for a new liver splitting program (ALERT-50).
Liver Transpl
January 2025
Hepato-biliary-pancreatic Surgery and Liver Transplantation Unit, Padua University Hospital, Padua, Italy.
Total hepatectomy and liver transplantation has emerged as a game-changing strategy in the treatment of several liver-confined primary or metastatic tumors, opening the new era of transplant oncology. However, the expansion of indications is going to worsen the chronic scarcity of organs, and new strategies are needed to enlarge the donor pool. A possible source of organs could be developing split liver transplantation (SLT) programs.
View Article and Find Full Text PDF[Expert consensus of perioperative management in split liver transplantation(2024)].
Zhonghua Wai Ke Za Zhi
January 2025
The donor organ shortage is still a "bottleneck" problem in the field of liver transplantation, and has been limiting the development of liver transplantation. In order to effectively expand the source of donor organs, transplant experts have also been thinking about technological innovation to solve this outstanding problem. Split liver transplantation is an effective strategy to solve the difficult problem, and it is a highly focused and applied technology in the transplantation field in recent years.
View Article and Find Full Text PDFEarly Hospital Readmission After Pediatric Liver Transplant: A Retrospective Analysis of the Society of Pediatric Liver Transplantation (SPLIT) Database.
Pediatr Transplant
February 2025
Department of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Introduction: Incidence of and risk factors for early hospital readmission (EHR) are poorly defined in pediatric liver transplant recipients. Therefore, we evaluated EHR incidence and risk factors for pediatric liver recipients in a nationally representative sample.
Methods: Using the Society of Pediatric Liver Transplantation database, we retrospectively analyzed 2808 pediatric liver-only recipients transplanted 2011-2022.
Unlocking the Promise of Liver Perfusion Technologies for Pediatric Transplantation: A State-of-the-Art Review.
Pediatr Transplant
December 2024
Recanati/Miller Transplantation Institute-Mount Sinai, New York, New York, USA.
Background: Outcomes after pediatric liver transplantation are generally excellent, but the limited avavailability of suitable, size-matched liver allografts remains a significant barrier. Machine perfusion technology has emerged as a promising approach to expand the donor pool, enabling the use of less ideal whole liver grafts, such as livers donated after circulatory death, and enhancing the execution of split liver transplantation.
Methods: This review examines the application of machine perfusion in pediatric liver transplantation, focusing on two primary techniques: hypothermic oxygentaed perfusion and normothermic machine perfusion.
Contrast-Enhanced Ultrasonography Findings Within 3 Days Postoperatively Are Associated With 1-Month Graft Failure After Split Liver Transplantation.
Acad Radiol
January 2025
Department of Ultrasound, the Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong Province, PR China; GuangDong Key Laboratory of Liver Disease Research, the Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, China. Electronic address:
Article Synopsis
- - The study investigated the effectiveness of Doppler ultrasonography (DUS) and contrast-enhanced ultrasonography (CEUS) in predicting graft failure one month after split liver transplantation in 58 patients.
- - Results showed that out of the 58 grafts, 7 failed within one month, with poor CEUS enhancement observed in 71.4% of those graft failures compared to 92.1% success in the remaining cases.
- - The analysis concluded that both the CEUS enhancement pattern and operative time are significant independent predictors of graft failure, suggesting CEUS could be a valuable tool in post-transplant assessments.
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